Abstract：
Currently, little is known regarding the association between dietary choline intake and osteoporosis in elderly individuals, as well as if such intakes affect bone health and result in fractures. This study was aimed to examine associations between daily dietary choline intake and osteoporosis in elderly individuals. A total of 31 034 participants from the National Health and Nutritional Examination Survey (NHANES) during 2005-2010 were enrolled, and 3179 participants with complete data and aged 65 years and older were identified. Baseline characteristics and dietary intake data were obtained through method of in-home administered questionnaires. Of 3179 individuals with a mean age of 73.7 ± 5.6 years, female (P < 0.001) and non-hispanic white (P < 0.001) occupied a higher proportion in the osteoporosis group. The logistic regression analysis indicated that the prevalence of osteoporosis in three tertile categories with gradually enhanced dietary choline intake was decreased progressively (P for trend <0.001). The restricted cubic spline (RCS) showed that the risk of osteoporosis generally decreased with increasing daily dietary choline intake (P < 0.001), while this trend was not apparent in relation between the daily dietary choline intake and risk of hip fracture (P = 0.592). The receiver operating characteristic (ROC) analysis identified a daily dietary choline intake of 232.1 mg as the optimal cutoff value for predicting osteoporosis. Our nationwide data suggested that a lower level of daily dietary choline intake was positively associated with the increased risk of osteoporosis in the US elderly population.
摘要：
目前,关于老年人膳食胆碱摄入量与骨质疏松症之间的关系知之甚少，以及如果这些摄入量影响骨骼健康并导致骨折。这项研究旨在研究老年人每日膳食胆碱摄入量与骨质疏松症之间的关系。在2005-2010年期间，共有31,034名来自国家健康和营养检查调查（NHANES）的参与者参加了研究。纳入了3179名数据完整且年龄在65岁及以上的参与者.通过家庭问卷调查的方法获得基线特征和饮食摄入数据。在3179名平均年龄为73.7±5.6岁的个体中，女性（P<0.001）和非西班牙裔白人（P<0.001）在骨质疏松症组中占更高的比例。logistic回归分析显示，随着膳食胆碱摄入量的逐渐增加，3个三元类骨质疏松症的患病率逐渐降低（P<0.001）。限制性三次样条（RCS）显示，骨质疏松症的风险通常随着每日膳食胆碱摄入量的增加而降低（P<0.001）。而每日膳食胆碱摄入量与髋部骨折风险之间的关系并不明显(P=0.592)。受试者工作特征（ROC）分析确定每日膳食胆碱摄入量为232.1mg作为预测骨质疏松症的最佳临界值。我们的全国数据表明，在美国老年人群中，每日膳食胆碱摄入量较低与骨质疏松症风险增加呈正相关。
