关键词: antimicrobial therapy antiviral therapy dendrimers diagnostics drug delivery infectious diseases nanoparticles

Mesh : Animals Anti-HIV Agents / pharmacology Anti-Infective Agents / pharmacology Bacterial Infections / drug therapy Biotechnology Catalysis Communicable Diseases / drug therapy Contrast Media Dendrimers / chemistry Drug Delivery Systems Drug Design HIV Infections / drug therapy Humans Infectious Disease Medicine / trends Magnetic Resonance Imaging Mice Nanotechnology Peptides / chemistry Polymers / chemistry Polypropylenes / chemistry SARS-CoV-2 Stereoisomerism Tomography, X-Ray Computed / trends Virus Diseases / drug therapy COVID-19 Drug Treatment

来  源:   DOI:10.3390/molecules26113304   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.
摘要:
树枝状聚合物包含一组特定的大分子,它结合了单分子和长膨胀聚合物的结构特性。树枝状聚合物的三维形式和使用其他底物进行构建的广泛可能性创造了多价潜力和广泛的医疗可能性,诊断和环境目的。根据它们的组成和结构,树枝状聚合物在许多科学领域都引起了人们的兴趣,从化学,生物技术在生化领域的应用。这些化合物已从催化剂的生产中获得了广泛的应用,用作抗菌剂,抗真菌和抗病毒药物。特别感兴趣的是肽树状聚合物作为运输治疗物质的介质:针对寄生虫的合成疫苗,细菌和病毒,MRI中使用的造影剂,抗体和遗传物质。这篇综述集中在描述当前类别的树枝状聚合物,它们的合成方法和它们的性质的简要缺点和它们作为潜在的治疗传染病的用途。
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