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Abstract：
Alzheimer\'s disease (AD) is a serious neurodegenerative disease, which seriously affects the behavior, cognition, and memory of patients. Studies have shown that sensory stimulation can effectively improve the cognition and memory of AD patients, and its role in brain plasticity and neural regulation is initially revealed. This paper aims to review the effect of various sensory stimulation and multisensory stimulation for AD, and to explain the possible mechanism, so as to provide some new ideas for further research in this field. We searched the Web of Science and PubMed databases (from 2000 to October 27, 2020) for literature on the treatment of AD with sensory and multisensory stimulation, including music therapy, aromatherapy, rhythmic (e.g., visual or acoustic) stimulation, light therapy, multisensory stimulation, and virtual reality assisted therapy, then conducted a systematic analysis. Results show these sensory and multisensory stimulations can effectively ameliorate the pathology of AD, arouse memory, and improve cognition and behaviors. What\'s more, it can cause brain nerve oscillation, enhance brain plasticity, and regulate regional cerebral blood flow. Sensory and multisensory stimulation are very promising therapeutic methods, and they play an important role in the improvement and treatment of AD, but their potential mechanism and stimulation parameters need to be explored and improved.
摘要：
阿尔茨海默病(Alzheimer’sdisease,AD)是一种严重的神经退行性疾病,严重影响了行为，认知，对病人的记忆。研究表明,感觉刺激能有效改善AD患者的认知和记忆,初步揭示了其在大脑可塑性和神经调节中的作用。本文旨在综述各种感觉刺激和多感觉刺激对AD的影响,并解释可能的机制，从而为该领域的进一步研究提供一些新的思路。我们搜索了WebofScience和PubMed数据库（从2000年到2020年10月27日），寻找关于用感觉和多感觉刺激治疗AD的文献。包括音乐疗法,芳香疗法,有节奏的(例如，视觉或听觉)刺激，光疗法,多感官刺激,和虚拟现实辅助治疗，然后进行了系统分析。结果表明，这些感觉和多感觉刺激可以有效改善AD的病理，唤起记忆，改善认知和行为。更重要的是，会引起脑神经振荡,增强大脑可塑性，调节局部脑血流量。感觉和多感觉刺激是非常有前途的治疗方法，它们在AD的改善和治疗中起着重要作用，但它们的潜在机制和刺激参数有待探索和改进。
