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Abstract：
This study investigated a 2-stage arterial switch operation (ASO) to treat transposition of the great arteries (TGA) with intact ventricular septum (TGA-IVS) in late referral patients.
We retrospectively analyzed patients with TGA-IVS or TGA with restricted ventricular septal defects who had undergone 2-stage ASO at our institution from February 2007 to August 2018. Included were 41 patients: 21 (51.2%) who had undergone long-term 2-stage ASO and 20 (48.8%) who had undergone rapid 2-stage ASO.
The long-term 2-stage group was older at ASO (3.5 vs 25 months; P < .001). Results were more satisfactory in the long-term group than in the rapid group for intensive care unit time (P = .004), mechanical ventilation time (P = .004), and length of stay (P = .007). No in-hospital death occurred in the long-term group, and the postoperative course was more manageable in the long-term group than in the rapid group. However, the risk of significant neoaortic regurgitation was lower in the rapid group, which also had a better left ventricular ejection fraction.
The long-term group achieved better early-term outcomes than the rapid group. However, a high risk of neoaortic regurgitation and myocardial dysfunction was also noted.
We retrospectively analyzed patients with TGA-IVS or TGA with restricted ventricular septal defects who had undergone 2-stage ASO at our institution from February 2007 to August 2018. Included were 41 patients: 21 (51.2%) who had undergone long-term 2-stage ASO and 20 (48.8%) who had undergone rapid 2-stage ASO.
The long-term 2-stage group was older at ASO (3.5 vs 25 months; P < .001). Results were more satisfactory in the long-term group than in the rapid group for intensive care unit time (P = .004), mechanical ventilation time (P = .004), and length of stay (P = .007). No in-hospital death occurred in the long-term group, and the postoperative course was more manageable in the long-term group than in the rapid group. However, the risk of significant neoaortic regurgitation was lower in the rapid group, which also had a better left ventricular ejection fraction.
The long-term group achieved better early-term outcomes than the rapid group. However, a high risk of neoaortic regurgitation and myocardial dysfunction was also noted.
摘要：
这项研究调查了2期动脉转换手术（ASO），以治疗晚期转诊患者的室间隔完整的大动脉转位（TGA-IVS）。
我们回顾性分析了2007年2月至2018年8月在我们机构接受2期ASO的TGA-IVS或TGA限制性室间隔缺损患者。包括41例患者：21例（51.2％）经历了长期2期ASO，20例（48.8％）经历了快速2期ASO。
长期2期组在ASO时年龄较大（3.5vs25个月；P<.001）。结果在长期组优于快速组重症监护病房时间（P=0.004），机械通气时间（P=.004），和停留时间(P=0.007)。长期组没有发生院内死亡，长期组的术后病程比快速组更易于管理。然而,快速组显著的新主动脉瓣反流风险较低,也有较好的左心室射血分数。
长期组取得了比快速组更好的早期结果。然而,我们还注意到新主动脉瓣反流和心肌功能障碍的高风险.
我们回顾性分析了2007年2月至2018年8月在我们机构接受2期ASO的TGA-IVS或TGA限制性室间隔缺损患者。包括41例患者：21例（51.2％）经历了长期2期ASO，20例（48.8％）经历了快速2期ASO。
长期2期组在ASO时年龄较大（3.5vs25个月；P<.001）。结果在长期组优于快速组重症监护病房时间（P=0.004），机械通气时间（P=.004），和停留时间(P=0.007)。长期组没有发生院内死亡，长期组的术后病程比快速组更易于管理。然而,快速组显著的新主动脉瓣反流风险较低,也有较好的左心室射血分数。
长期组取得了比快速组更好的早期结果。然而,我们还注意到新主动脉瓣反流和心肌功能障碍的高风险.
