PDF(Pubmed)
Abstract：
BACKGROUND: Fever is the most common complaint among the children admitted to health care centers. The aim of this study was to compare the anti-pyretic effect of diclofenac and high dose acetaminophen suppository in 1 to 6 years old children.
METHODS: This double-blind clinical trial study was performed on 1-6-year-old children hospitalized in 17th Shahrivar Teaching Hospital, Rasht, Iran. Children were divided into two groups of 45 using a block randomization design. The first group received a high dose of acetaminophen suppository at a dose of 30 mg/kg and the second group received a diclofenac suppository at a dose of 1 mg/kg. The rectal temperature of the patients was measured using a digital thermometer at the time of drug administration, and one and three hours after that.
RESULTS: 90 children were studied in two groups of 45 each. Temperature changes in the diclofenac group were significantly greater than the acetaminophen group, so from zero to 3 hours after administering diclofenac, the temperature decreased to 1.76±0.95°C. This reduction was lower in acetaminophen group (1.26±0.49°C, P=0.019).
CONCLUSIONS: Both acetaminophen and diclofenac suppositories significantly reduced the rectal temperature. However, the effect of rectal diclofenac on reducing temperature is more than rectal acetaminophen.
METHODS: This double-blind clinical trial study was performed on 1-6-year-old children hospitalized in 17th Shahrivar Teaching Hospital, Rasht, Iran. Children were divided into two groups of 45 using a block randomization design. The first group received a high dose of acetaminophen suppository at a dose of 30 mg/kg and the second group received a diclofenac suppository at a dose of 1 mg/kg. The rectal temperature of the patients was measured using a digital thermometer at the time of drug administration, and one and three hours after that.
RESULTS: 90 children were studied in two groups of 45 each. Temperature changes in the diclofenac group were significantly greater than the acetaminophen group, so from zero to 3 hours after administering diclofenac, the temperature decreased to 1.76±0.95°C. This reduction was lower in acetaminophen group (1.26±0.49°C, P=0.019).
CONCLUSIONS: Both acetaminophen and diclofenac suppositories significantly reduced the rectal temperature. However, the effect of rectal diclofenac on reducing temperature is more than rectal acetaminophen.
摘要：
背景：发热是入住卫生保健中心的儿童中最常见的主诉。这项研究的目的是比较双氯芬酸和大剂量对乙酰氨基酚栓剂对1至6岁儿童的退热作用。
方法：这项双盲临床试验研究是对17Shahrivar教学医院住院的1-6岁儿童进行的，Rasht,伊朗。使用区组随机化设计将儿童分为两组，每组45人。第一组以30mg/kg的剂量接受高剂量的对乙酰氨基酚栓剂,第二组以lmg/kg的剂量接受双氯芬酸栓剂。给药时用数字体温计测量患者的直肠温度,在那之后的一两个小时.
结果：90名儿童被分为两组，每组45名。双氯芬酸组的温度变化明显大于对乙酰氨基酚组，所以在服用双氯芬酸之后零到三小时,温度下降到1.76±0.95℃。这种降低在对乙酰氨基酚组中较低（1.26±0.49°C，P=0.019)。
结论：对乙酰氨基酚和双氯芬酸栓剂均能显著降低直肠温度。然而,直肠双氯芬酸对降低温度的作用比直肠对乙酰氨基酚更大。
方法：这项双盲临床试验研究是对17Shahrivar教学医院住院的1-6岁儿童进行的，Rasht,伊朗。使用区组随机化设计将儿童分为两组，每组45人。第一组以30mg/kg的剂量接受高剂量的对乙酰氨基酚栓剂,第二组以lmg/kg的剂量接受双氯芬酸栓剂。给药时用数字体温计测量患者的直肠温度,在那之后的一两个小时.
结果：90名儿童被分为两组，每组45名。双氯芬酸组的温度变化明显大于对乙酰氨基酚组，所以在服用双氯芬酸之后零到三小时,温度下降到1.76±0.95℃。这种降低在对乙酰氨基酚组中较低（1.26±0.49°C，P=0.019)。
结论：对乙酰氨基酚和双氯芬酸栓剂均能显著降低直肠温度。然而,直肠双氯芬酸对降低温度的作用比直肠对乙酰氨基酚更大。
