Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass.

体外循环后小儿先天性心脏病的菌群失调和肠屏障功能障碍加剧。

• 影响指数: 9.531
• 发表时间: Apr 2021
• 来源期刊: JACC Basic Transl Sci
• DOI: 10.1016/j.jacbts.2020.12.012
• PMID: 33997519
• 文章类型: Journal Article
• 作者列表: Salomon J,Ericsson A,Price A,Manithody C,Murry DJ,Chhonker YS,Buchanan P,Lindsey ML,Singh AB,Jain AK

关键词: ANOVA, analysis of variance; CHD, congenital heart disease; CPB, cardiopulmonary bypass; DNA, deoxyribonucleic acid; EBD, epithelial barrier dysfunction; FABP2, fatty acid binding protein 2; LCOS, low–cardiac output syndrome; NPO, nil per os; OTU, operational taxonomic unit; PGE2, prostaglandin E2; RA, relative abundance; bacterial interactions; cardiovascular disease; enteric bacterial microflora; intestinal barrier function; intestinal microbiology; rRNA, ribosomal ribonucleic acid

Abstract

There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.

摘要

没有数据评估体外循环后先天性心脏病的微生物组。作者评估了接受体外循环的先天性心脏病患者和未接受搭桥手术的非心脏患者。先天性心脏病患者与对照组相比，基线微生物组有差异，这种情况在搭桥手术后加剧。基线时，两组的屏障功能障碍标志物相似，与对照组相比，搭桥手术引起明显的肠屏障功能障碍。这项研究提供了先天性心脏病和恶化以及体外循环后肠屏障功能障碍的微生物组改变的新证据。