PDF(Pubmed)
Abstract：
The purpose of the study was to determine whether neuromuscular electrical stimulation resistance training (NMES-RT)-evoked muscle hypertrophy is accompanied by increased V̇o2 peak, ventilatory efficiency, and mitochondrial respiration in individuals with chronic spinal cord injury (SCI). Thirty-three men and women with chronic, predominantly traumatic SCI were randomized to either NMES-RT (n = 20) or passive movement training (PMT; n = 13). Functional electrical stimulation-lower extremity cycling (FES-LEC) was used to test the leg V̇o2 peak, V̇E/V̇co2 ratio, and substrate utilization pre- and postintervention. Magnetic resonance imaging was used to measure muscle cross-sectional area (CSA). Finally, muscle biopsy was performed to measure mitochondrial complexes and respiration. The NMES-RT group showed a significant increase in postintervention V̇o2 peak compared with baseline (ΔV̇o2 = 14%, P < 0.01) with no changes in the PMT group (ΔV̇o2 = 1.6%, P = 0.47). Similarly, thigh (ΔCSAthigh = 19%) and knee extensor (ΔCSAknee = 30.4%, P < 0.01) CSAs increased following NMES-RT but not after PMT. The changes in thigh and knee extensor muscle CSAs were positively related with the change in V̇o2 peak. Neither NMES-RT nor PMT changed mitochondrial complex tissue levels; however, changes in peak V̇o2 were related to complex I. In conclusion, in persons with SCI, NMES-RT-induced skeletal muscle hypertrophy was accompanied by increased peak V̇o2 consumption which may partially be explained by enhanced activity of mitochondrial complex I.NEW & NOTEWORTHY Leg oxygen uptake (V̇o2) and ventilatory efficiency (V̇E/V̇co2 ratio) were measured during functional electrical stimulation cycling testing following 12-16 wk of either electrically evoked resistance training or passive movement training, and the respiration of mitochondrial complexes. Resistance training increased thigh muscle area and leg V̇o2 peak but decreased V̇E/V̇co2 ratio without changes in mitochondrial complex levels. Leg V̇o2 peak was associated with muscle hypertrophy and mitochondrial respiration of complex I following training.
摘要：
该研究的目的是确定神经肌肉电刺激阻力训练（NMES-RT）诱发的肌肉肥大是否伴随着Vo2峰值的增加，通气效率，慢性脊髓损伤（SCI）患者的线粒体呼吸。33名男性和女性患有慢性疾病，以创伤性SCI为主的患者被随机分为NMES-RT(n=20)或被动运动训练(PMT;n=13).功能性电刺激-下肢循环（FES-LEC）用于测试腿部Vo2峰，V^E/V^co2比值，干预前后的底物利用。磁共振成像用于测量肌肉横截面积（CSA）。最后,进行肌肉活检以测量线粒体复合物和呼吸.与基线相比，NMES-RT组的干预后V_o2峰值显着增加（ΔV_o2=14％，P<0.01），PMT组无变化（ΔVo2=1.6％，P=0.47）。同样，大腿(ΔCSAthigh=19%)和膝关节伸肌(ΔCSAknee=30.4%,P<0.01)CSAs在NMES-RT后增加，但在PMT后不增加。大腿和膝关节伸肌CSAs的变化与V_O2峰的变化呈正相关。NMES-RT和PMT均未改变线粒体复合物组织水平；然而，峰值V的变化与复杂的I相关。在SCI患者中，NMES-RT诱导的骨骼肌肥大伴随着峰值Vo2消耗的增加，这可能部分解释为线粒体复合物I.NEW和NOTEWORTHY腿部摄氧量（Vo2）和通气效率（VE/Vco2比率）在电诱发阻力训练或被动运动训练后12-16周的功能性电刺激循环测试中进行测量，和线粒体复合物的呼吸。抗阻训练增加了大腿肌肉面积和腿部V_o2峰值，但降低了V_E/V_co2比值，而线粒体复合物水平没有变化。腿V的o2峰与训练后复合物I的肌肉肥大和线粒体呼吸有关。
