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Abstract：
Acanthocheilonema reconditum is a filarial parasite transmitted by arthropods (fleas, lice, and ticks) that infect dogs. There is minimal published data available to date on potential haematological and biochemical changes associated with this parasitic infection. Study aims were (i) provide an overview of A. reconditum in Europe, (ii) define A. reconditum prevalence and risk factors in a specific dog population (hunting) from southern Italy, and (iii) assess the frequency of haemato-biochemical abnormalities associated with infection. Blood samples collected from 3020 dogs were tested by a modified Knott\'s technique to count and identify microfilariae. Eighty-four dogs were infected by A. reconditum (2.78%; 95% CI 2.19-3.37%). Microfilariae ranged from 1 to 212/ml. Based on clinical examination, all but six dogs with non-specific symptoms were healthy. Haematological abnormalities included leucocytosis (n = 15), with eosinophilia (n = 14) and monocytosis (n = 13). Serum biochemical abnormalities included increased total serum proteins (n = 19), albumins (n = 7), total globulins (n = 14), ALT (n = 1), and ALP (n = 1); one dog was hypoalbuminemic, and BUN was mildly increased in 2 dogs. Risk factors included the province origin (Napoli, OR=5.4, 95%CI: 2.1-14.0; Caserta, OR=5.1, 95%CI: 2.5-10.6), hunting wild mammals (OR=2.8, 95% 95%CI: 1.6-4.8), and ectoparasite infestation (OR=1.9, 95%CI: 1.1-3.1). There was a negative correlation between microfilaraemic load and decreased albumin level (-0.37; p=0.021). Our results showed that A. reconditum circulates within the hunting dog population of southern Italy, with seemingly low pathogenic potential.
摘要：
Acanthocheilonemareconditum是一种由节肢动物传播的丝虫寄生虫（跳蚤，虱子,和蜱虫）感染狗。迄今为止，关于与这种寄生虫感染有关的潜在血液学和生化变化的可用数据很少。研究目的是(I)概述欧洲的A.reconditum，（ii）定义意大利南部特定狗种群（狩猎）的A.reconditum患病率和危险因素，和(iii)评估与感染相关的血液生化异常的频率。通过改良的Knott's技术对从3020只狗收集的血液样本进行了测试，以计数和鉴定微丝虫。84只狗感染了A.reconditum（2.78％；95％CI2.19-3.37％）。微丝虫的范围为1至212/ml。根据临床检查，除6条有非特异性症状的狗外,其余狗均健康.血液学异常包括白细胞增多症（n=15），嗜酸性粒细胞增多（n=14）和单核细胞增多（n=13）。血清生化异常包括血清总蛋白升高（n=19），白蛋白（n=7），总球蛋白（n=14），ALT（n=1），和ALP（n=1）；一只狗是低蛋白血症，2只狗的BUN轻度增加。风险因素包括省份(那不勒斯，OR=5.4，95CI：2.1-14.0；卡塞塔，OR=5.1，95CI：2.5-10.6），狩猎野生哺乳动物（OR=2.8，95％95CI：1.6-4.8），和体外寄生虫侵染（OR=1.9，95CI：1.1-3.1）。微丝血负荷与白蛋白水平降低呈负相关（-0.37；p=0.021）。我们的结果表明，A.reconditum在意大利南部的猎犬种群中循环，具有看似低致病潜力。
