Abstract：
Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.
摘要：
Wnt激活的髓母细胞瘤（MB）具有良好的预后。然而,复发性Wnt-MB患者的具体治疗策略未知.我们报告了两名通过合并骨髓消融化疗和自体造血祖细胞抢救（HDCx/AuHPCR）成功治疗的复发性β-catenin核阳性Wnt-MB患者。我们还对先前报道的复发性Wnt-MB病例进行了文献综述。我们建议可以使用多学科方法治疗复发性Wnt-MB患者，包括HDCx/AuHPCR，有或没有再次照射。
