%0 Journal Article
%T Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature.
%A Harris MK
%A Shatara M
%A Funk Z
%A Stanek J
%A Boué DR
%A Jones J
%A Finlay JL
%A Abdelbaki MS
%J Childs Nerv Syst
%V 0
%N 0
%D May 2021 4
%M 33948723
%F 1.532
%R 10.1007/s00381-021-05197-6
%X Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.