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Abstract：
Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.
摘要：
造血多能祖细胞播种胸腺，然后遵循连续的发育阶段，直到形成成熟的T细胞。在这个过程中,T细胞的表型变化需要阶段特异性转录程序，这是成熟淋巴细胞动态发展的基础。谱系特异性转录因子是T细胞特化的关键驱动因素，并与表观遗传调节因子一起发挥作用，表观遗传调节因子也被阐明为建立适当T细胞发育所必需的调节网络的关键参与者。在这次审查中,我们总结了转录因子和表观遗传调节因子的活性，它们共同协调了早期T细胞发育的复杂性，重点是T细胞谱系承诺的调节。
