{Reference Type}: Journal Article
{Title}: The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.
{Author}: Chiara VD;Daxinger L;Staal FJT;
{Journal}: Cells
{Volume}: 10
{Issue}: 5
{Year}: 04 2021 30
{Factor}: 7.666
{DOI}: 10.3390/cells10051074
{Abstract}: Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.