棕色脂肪组织中的 OPA1 缺失通过 FGF21 改善体温调节和全身代谢。
关键词: activating transcription factor 4 biochemistry brown adipose tissue browning chemical biology fibroblast growth factor 21 mouse optic atrophy 1 thermogenesis
Mesh : Adipocytes, Brown / physiology Adipose Tissue, Brown / metabolism Adipose Tissue, White / physiology Animals Body Temperature Regulation / genetics Female Fibroblast Growth Factors / genetics metabolism GTP Phosphohydrolases / genetics Gene Deletion Male Mice Mice, Inbred C57BL Mice, Knockout Obesity / genetics
来 源:
DOI:10.7554/eLife.66519
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