PDF(Pubmed)
Abstract：
Cutaneous leishmaniasis (CL) is an emergent public health concern, particularly in tropical and subtropical regions. Reports of pregnancy complications are scarce; however, as the endemic range of CL expands in Iran, there is concern of possible detrimental effects on fetal development amongst infected mothers through placental transmission of the parasite or enhanced maternal immune responses. We herein describe the first known case of persistent anthroponotic CL, plausibly responsible for pregnancy complications, preterm birth, and neonatal death in a healthy Iranian primigravida woman. Diagnosis was based on physical examinations of the lesions on the back of both calves of the patient and laboratory analyses including direct smear, culture, and PCR. During active CL infection, the patient gave birth to a premature female neonate who passed three days post-delivery due to immature lung development and subsequent respiratory distress syndrome. This report highlights the challenges associated with CL infection during pregnancy, exacerbation of lesions, and subsequent complications.
摘要：
皮肤利什曼病（CL）是一个新兴的公共卫生问题，特别是在热带和亚热带地区。妊娠并发症的报告很少；然而，随着CL在伊朗的流行范围扩大，人们担心，通过胎盘传播寄生虫或增强母体免疫反应，感染母亲可能会对胎儿发育产生有害影响。我们在此描述了第一个已知的持续性降肌痛的病例，可能是怀孕并发症的原因，早产,一名健康的伊朗primigravida妇女的新生儿死亡。诊断基于患者小腿背部病变的体格检查和实验室分析，包括直接涂片，文化,和PCR。在活动性CL感染期间，该患者生下一名早产的女性新生儿,由于肺部发育不成熟和随后的呼吸窘迫综合征,该新生儿在分娩后3天通过.这份报告强调了怀孕期间与CL感染相关的挑战，病变恶化，以及随后的并发症。
