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Abstract：
Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a physiological setting. In turn, the electronic properties and supramolecular chemistry of metal complexes can be exploited to characterize drug delivery nanosystems by NMR. The recent evolution of in-cell NMR methodology is presented with special emphasis on metal-related processes. Applications to paradigmatic cases of platinum and gold drugs are highlighted.
摘要：
基于金属的药物可以调节各种生物过程，并表现出丰富多样的特性，这些特性促进了它们在生物医学和化学生物学中的应用。在通往细胞内靶标的路上，配体交换和氧化还原反应可以发生，因此使体内的金属药物形态成为一项具有挑战性的任务。NMR光谱学的进步使人们有可能从溶液研究转向活细胞研究，并阐明在生理环境中金属药物的运输以及与大分子靶标的相互作用。反过来,金属配合物的电子性质和超分子化学可以通过NMR表征药物递送纳米系统。介绍了电池内NMR方法的最新发展，特别强调了与金属相关的过程。重点介绍了铂和金药物的典型案例。
