PDF(Pubmed)
Abstract：
This study explored the effect of kinesthetic motor imagery training on reaching-to-grasp movement supplemented by a virtual environment in a patient with congenital bilateral transverse upper-limb deficiency. Based on a theoretical assumption, it is possible to conduct such training in this patient. The aim of this study was to evaluate whether cortical activity related to motor imagery of reaching and motor imagery of grasping of the right upper limb was changed by computer-aided imagery training (CAIT) in a patient who was born without upper limbs compared to a healthy control subject, as characterized by multi-channel electroencephalography (EEG) signals recorded before and 4, 8, and 12 weeks after CAIT. The main task during CAIT was to kinesthetically imagine the execution of reaching-to-grasp movements without any muscle activation, supplemented by computer visualization of movements provided by a special headset. Our experiment showed that CAIT can be conducted in the patient with higher vividness of imagery for reaching than grasping tasks. Our results confirm that CAIT can change brain activation patterns in areas related to motor planning and the execution of reaching and grasping movements, and that the effect was more pronounced in the patient than in the healthy control subject. The results show that CAIT has a different effect on the cortical activity related to the motor imagery of a reaching task than on the cortical activity related to the motor imagery of a grasping task. The change observed in the activation patterns could indicate CAIT-induced neuroplasticity, which could potentially be useful in rehabilitation or brain-computer interface purposes for such patients, especially before and after transplantation. This study was part of a registered experiment (ID: NCT04048083).
摘要：
这项研究探讨了动觉运动想象训练对先天性双侧横向上肢缺陷患者的虚拟环境辅助的伸手动作的影响。基于理论假设，有可能在这个病人身上进行这样的训练。这项研究的目的是评估与上肢出生时没有上肢的患者相比，通过计算机辅助图像训练（CAIT）是否改变了与右上肢的运动图像有关的皮层活动与健康对照受试者，其特征是在CAIT之前和之后4、8和12周记录的多通道脑电图（EEG）信号。CAIT的主要任务是在没有任何肌肉激活的情况下，从运动学上想象抓握动作的执行，由特殊耳机提供的运动的计算机可视化补充。我们的实验表明，与抓握任务相比，CAIT可以在具有更高的图像生动度的患者中进行。我们的结果证实，CAIT可以改变与运动计划以及伸手和抓握运动的执行相关区域的大脑激活模式，并且这种效果在患者中比在健康对照受试者中更明显。结果表明，CAIT对与伸手任务的运动意象相关的皮层活动的影响与对与抓握任务的运动意象相关的皮层活动的影响不同。在激活模式中观察到的变化可能表明CAIT诱导的神经可塑性，这可能对这类患者的康复或脑机接口有用，尤其是移植前后。该研究是注册实验的一部分(ID:NCT04048083)。
