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Abstract：
Toxoplasmosis is one of the most frequent food-borne infections in humans caused by an obligate intracellular protozoan parasite, Toxoplasma gondii. Rodents, as intermediate and reservoir hosts, play key role in the epidemiology of toxoplasmosis; because they are the main source of infection for the Felidae family members and establish the parasite life cycle. Hence, the infectious isolates of T. gondii in rodents may be the main genotypes infecting the environment, humans and animals. Our review aimed to present the population structure of T. gondii in these mammals. To access the relevant studies, six English language databases were systematically searched from 1990 to 2019. Finally, 3,395 samples of rodents were analysed for the genotyping data and 118 isolates were separated from the samples. The results of the present study showed that atypical genotypes were dominant with a frequency of 65.2% of the total isolates (77 out of 118). Clonal Types II, III and I had less frequency, respectively. Type I clonal isolates were identified only from Asia. The examination of genotypes circulating in rodents around the world revealed that ToxoDB #1 or #3 (Type II) were the most common, followed by ToxoDB #9 and #2, respectively. Overall, our data showed low genetic diversity of T. gondii with circulating clonal strains in rodents compare to the isolates from Europe, North America and Africa, while non-clonal parasites with high genetic diversity were dominant in South America and Asia.
摘要：
弓形虫病是由专性细胞内原生动物寄生虫引起的人类最常见的食源性感染之一，弓形虫.啮齿动物,作为中间和水库宿主，在弓形虫病的流行病学中起关键作用；因为它们是Felidae家族成员的主要感染源，并建立了寄生虫的生命周期。因此，鼠类感染弓形虫的分离株可能是感染环境的主要基因型,人类和动物。我们的综述旨在介绍这些哺乳动物中弓形虫的种群结构。要访问相关研究，从1990年到2019年，系统地搜索了六个英语数据库。最后,分析了3,395个啮齿动物样品的基因分型数据，并从样品中分离出118个分离株。本研究的结果表明，非典型基因型占主导地位，占总分离株的65.2％（118个中的77个）。II型克隆,III和我的频率较低，分别。仅从亚洲鉴定了I型克隆分离株。对世界各地啮齿动物中流行的基因型的检查表明，ToxoDB#1或#3（II型）是最常见的，其次是ToxoDB#9和#2。总的来说,我们的数据显示，与来自欧洲的分离株相比，在啮齿动物中具有循环克隆菌株的弓形虫的遗传多样性较低，北美和非洲，而具有高遗传多样性的非克隆寄生虫在南美和亚洲占主导地位。
