关键词： cholesterol homeostasis fucosterol inflammation marine steroids neurodegeneration oxidative stress

Mesh ： Alzheimer Disease / drug therapy immunology metabolism pathology Animals Anti-Inflammatory Agents / isolation & purification pharmacokinetics pharmacology Antioxidants / isolation & purification pharmacology Aquatic Organisms / metabolism Brain / drug effects immunology metabolism pathology Cholesterol / metabolism Homeostasis Humans Inflammation Mediators / metabolism Neuroprotective Agents / isolation & purification pharmacokinetics pharmacology Oxidative Stress / drug effects Sterols / isolation & purification pharmacokinetics pharmacology

来  源：   DOI：10.3390/md19030167   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Alzheimer\'s disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer\'s agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer\'s activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.
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