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Abstract：
To assess the efficacy of intensity-modulated radiation therapy (IMRT) for tumors of the nasal cavity and paranasal sinus (PNS) region.
Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis.
Fifty-one (24.1%) received definitive RT/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow-up was 43.5 months. The 5-year local control (LC), event-free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated/poorly differentiated histology were associated with inferior 5-year LC, EFS, and OS. Four patients had late Grade 3/Grade 4 ocular toxicity.
IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.
Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis.
Fifty-one (24.1%) received definitive RT/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow-up was 43.5 months. The 5-year local control (LC), event-free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated/poorly differentiated histology were associated with inferior 5-year LC, EFS, and OS. Four patients had late Grade 3/Grade 4 ocular toxicity.
IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.
摘要：
评价调强放疗(IMRT)治疗鼻腔鼻窦(PNS)区肿瘤的疗效。
这项回顾性分析包括2007年至2019年间接受根治性IMRT治疗的214例鼻腔和PNS区域肿瘤患者。
51(24.1%)接受确定性RT/CTRT,163(75.9%)接受佐剂RT。最常见的组织学是鳞状细胞癌（26.1％），其次是腺样囊性癌（21.5％）。中位随访时间为43.5个月。5年本地控制（LC），无事件生存（EFS），整个队列的总生存率（OS）为66.9%，59%,73.9%，分别。在非手术方式的单因素分析治疗中，T分类和未分化/低分化组织学与5年下LC相关，EFS,和OS。四名患者具有晚期3级/4级眼部毒性。
在所有组织学和治疗环境中，IMRT应该是PNS区域肿瘤的护理标准。
这项回顾性分析包括2007年至2019年间接受根治性IMRT治疗的214例鼻腔和PNS区域肿瘤患者。
51(24.1%)接受确定性RT/CTRT,163(75.9%)接受佐剂RT。最常见的组织学是鳞状细胞癌（26.1％），其次是腺样囊性癌（21.5％）。中位随访时间为43.5个月。5年本地控制（LC），无事件生存（EFS），整个队列的总生存率（OS）为66.9%，59%,73.9%，分别。在非手术方式的单因素分析治疗中，T分类和未分化/低分化组织学与5年下LC相关，EFS,和OS。四名患者具有晚期3级/4级眼部毒性。
在所有组织学和治疗环境中，IMRT应该是PNS区域肿瘤的护理标准。
