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Abstract：
To perform a multicenter study to assess growth failure in hospitalized infants with gastroschisis.
This study included neonates with gastroschisis within sites in the University of California Fetal Consortium. The study\'s primary outcome was growth failure at hospital discharge, defined as a weight or length z score decrease >0.8 from birth. Regression analysis was performed to assess changes in z scores over time.
Among 125 infants with gastroschisis, the median gestational age was 37 weeks (IQR 35-37). Length of stay was 32 days (23-60); 55% developed weight or length growth failure at discharge (28% had weight growth failure, 42% had length growth failure, and 15% had both weight and length growth failure). Weight and length z scores at 14 days, 30 days, and discharge were less than birth (P < .01 for all). Weight and length z scores declined from birth to 30 days (-0.10 and -0.11 z score units/week, respectively, P < .001). Length growth failure at discharge was associated with weight and length z score changes over time (P < .05 for both). Lower gestational age was associated with weight growth failure (OR 0.70 for each gestational age week, 95% CI 0.55-0.89, P = .004).
Growth failure, in particular linear growth failure, is common in infants with gastroschisis. These data suggest the need to improve nutritional management in these infants.
This study included neonates with gastroschisis within sites in the University of California Fetal Consortium. The study\'s primary outcome was growth failure at hospital discharge, defined as a weight or length z score decrease >0.8 from birth. Regression analysis was performed to assess changes in z scores over time.
Among 125 infants with gastroschisis, the median gestational age was 37 weeks (IQR 35-37). Length of stay was 32 days (23-60); 55% developed weight or length growth failure at discharge (28% had weight growth failure, 42% had length growth failure, and 15% had both weight and length growth failure). Weight and length z scores at 14 days, 30 days, and discharge were less than birth (P < .01 for all). Weight and length z scores declined from birth to 30 days (-0.10 and -0.11 z score units/week, respectively, P < .001). Length growth failure at discharge was associated with weight and length z score changes over time (P < .05 for both). Lower gestational age was associated with weight growth failure (OR 0.70 for each gestational age week, 95% CI 0.55-0.89, P = .004).
Growth failure, in particular linear growth failure, is common in infants with gastroschisis. These data suggest the need to improve nutritional management in these infants.
摘要：
进行多中心研究以评估住院腹裂婴儿的生长障碍。
这项研究包括在加利福尼亚大学胎儿协会的研究中出现腹裂的新生儿。该研究的主要结果是出院时的生长障碍，定义为体重或身长z评分从出生时下降>0.8。进行回归分析以评估z评分随时间的变化。
在125名患有腹裂的婴儿中，中位胎龄为37周(IQR35-37).住院时间为32天（23-60天）；55％的人在出院时出现体重增长失败或长度增长失败（28％的人体重增长失败，42%有长度生长失败，和15%有体重和长度生长失败)。14天的体重和身长z评分，30天,出院时间少于出生（P<0.01）。体重和身长z分数从出生到30天下降(-0.10和-0.11z分数单位/周，分别,P<.001)。出院时的长度生长失败与体重和长度z评分随时间变化相关（两者P<0.05）。较低的胎龄与体重增长障碍相关（每个胎龄为0.70，95%CI0.55-0.89，P=.004）。
成长失败，特别是线性增长失败，常见于患有腹裂的婴儿。这些数据表明需要改善这些婴儿的营养管理。
这项研究包括在加利福尼亚大学胎儿协会的研究中出现腹裂的新生儿。该研究的主要结果是出院时的生长障碍，定义为体重或身长z评分从出生时下降>0.8。进行回归分析以评估z评分随时间的变化。
在125名患有腹裂的婴儿中，中位胎龄为37周(IQR35-37).住院时间为32天（23-60天）；55％的人在出院时出现体重增长失败或长度增长失败（28％的人体重增长失败，42%有长度生长失败，和15%有体重和长度生长失败)。14天的体重和身长z评分，30天,出院时间少于出生（P<0.01）。体重和身长z分数从出生到30天下降(-0.10和-0.11z分数单位/周，分别,P<.001)。出院时的长度生长失败与体重和长度z评分随时间变化相关（两者P<0.05）。较低的胎龄与体重增长障碍相关（每个胎龄为0.70，95%CI0.55-0.89，P=.004）。
成长失败，特别是线性增长失败，常见于患有腹裂的婴儿。这些数据表明需要改善这些婴儿的营养管理。
