{Reference Type}: Journal Article
{Title}: Growth Failure Prevalence in Neonates with Gastroschisis : A Statewide Cohort Study.
{Author}: Strobel KM;Romero T;Kramer K;Fernandez E;Rottkamp C;Uy C;Keller R;Moyer L;Poulain F;Kim JH;DeUgarte DA;Calkins KL; ;
{Journal}: J Pediatr
{Volume}: 233
{Issue}: 0
{Year}: 06 2021
{Factor}: 6.314
{DOI}: 10.1016/j.jpeds.2021.02.013
{Abstract}: To perform a multicenter study to assess growth failure in hospitalized infants with gastroschisis.<BR>This study included neonates with gastroschisis within sites in the University of California Fetal Consortium. The study's primary outcome was growth failure at hospital discharge, defined as a weight or length z score decrease >0.8 from birth. Regression analysis was performed to assess changes in z scores over time.<BR>Among 125 infants with gastroschisis, the median gestational age was 37 weeks (IQR 35-37). Length of stay was 32 days (23-60); 55% developed weight or length growth failure at discharge (28% had weight growth failure, 42% had length growth failure, and 15% had both weight and length growth failure). Weight and length z scores at 14 days, 30 days, and discharge were less than birth (P < .01 for all). Weight and length z scores declined from birth to 30 days (-0.10 and -0.11 z score units/week, respectively, P < .001). Length growth failure at discharge was associated with weight and length z score changes over time (P < .05 for both). Lower gestational age was associated with weight growth failure (OR 0.70 for each gestational age week, 95% CI 0.55-0.89, P = .004).<BR>Growth failure, in particular linear growth failure, is common in infants with gastroschisis. These data suggest the need to improve nutritional management in these infants.