巨噬细胞作为宿主 ,利什曼病中的效应细胞和免疫调节细胞 : 组织微环境和代谢的影响。
关键词: (L)CL, (localized) cutaneous leishmaniasis AHR, aryl hydrocarbon receptor AMP, antimicrobial peptide Arg, arginase Arginase CAMP, cathelicidin-type antimicrobial peptide CR, complement receptor DC, dendritic cells DCL, diffuse cutaneous leishmaniasis HO-1, heme oxygenase 1 Hypoxia IDO, indoleamine-2,3-dioxygenase IFN, interferon IFNAR, type I IFN (IFN-α/β) receptor IL, interleukin Interferon-α/β Interferon-γ JAK, Janus kinase LPG, lipophosphoglycan LRV1, Leishmania RNA virus 1 Leishmaniasis Macrophages Metabolism NCX1, Na+/Ca2+ exchanger 1 NFAT5, nuclear factor of activated T cells 5 NK cell, natural killer cell NO, nitric oxide NOS2 (iNOS), type 2 (or inducible) nitric oxide synthase NOX2, NADPH oxidase 2 (gp91 or cytochrome b558 β-subunit of Phox) Nitric oxide OXPHOS, mitochondrial oxidative phosphorylation PKDL, post kala-azar dermal leishmaniasis Phagocyte NADPH oxidase Phox, phagocyte NADPH oxidase RNS, reactive nitrogen species ROS, reactive oxygen species SOCS, suppressor of cytokine signaling STAT, signal transducer and activator of transcription TGF-β, transforming growth factor-beta TLR, toll-like receptor Th1 (Th2), type 1 (type2) T helper cell Tonicity VL, visceral leishmaniasis mTOR, mammalian/mechanistic target of rapamycin
来 源:
DOI:10.1016/j.cytox.2020.100041
PDF(Sci-hub)
PDF(Pubmed)