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Abstract：
UNASSIGNED: Prospective cohort.
UNASSIGNED: To prospectively evaluate PROs up to 5-years after complex ASD surgery.
UNASSIGNED: The Scoli-RISK-1 study enrolled 272 ASD patients undergoing surgery from 15 centers. Inclusion criteria was Cobb angle of >80°, corrective osteotomy for congenital or revision deformity, and/or 3-column osteotomy. The following PROs were measured prospectively at intervals up to 5-years postoperative: ODI, SF36-PCS/MCS, SRS-22, NRS back/leg. Among patients with 5-year follow-up, comparisons were made from both baseline and 2-years postoperative to 5-years postoperative. PROs were analyzed using mixed models for repeated measures.
UNASSIGNED: Seventy-seven patients (28.3%) had 5-year follow-up data. Comparing baseline to 5-year data among these 77 patients, significant improvement was seen in all PROs: ODI (45.2 vs. 29.3, P < 0.001), SF36-PCS (31.5 vs. 38.8, P < 0.001), SF36-MCS (44.9 vs. 49.1, P = 0.009), SRS-22-total (2.78 vs. 3.61, P < 0.001), NRS-back pain (5.70 vs. 2.95, P < 0.001) and NRS leg pain (3.64 vs. 2.62, P = 0.017). In the 2 to 5-year follow-up period, no significant changes were seen in any PROs. The percentage of patients achieving MCID from baseline to 5-years were: ODI (62.0%) and the SRS-22r domains of function (70.4%), pain (63.0%), mental health (37.5%), self-image (60.3%), and total (60.3%). Surprisingly, mean values (P > 0.05) and proportion achieving MCID did not differ significantly in patients with major surgery-related complications compared to those without.
UNASSIGNED: After complex ASD surgery, significant improvement in PROs were seen at 5-years postoperative in ODI, SF36-PCS/MCS, SRS-22r, and NRS-back/leg pain. No significant changes in PROs occurred during the 2 to 5-year postoperative period. Those with major surgery-related complications had similar PROs and proportion of patients achieving MCID as those without these complications.
UNASSIGNED: To prospectively evaluate PROs up to 5-years after complex ASD surgery.
UNASSIGNED: The Scoli-RISK-1 study enrolled 272 ASD patients undergoing surgery from 15 centers. Inclusion criteria was Cobb angle of >80°, corrective osteotomy for congenital or revision deformity, and/or 3-column osteotomy. The following PROs were measured prospectively at intervals up to 5-years postoperative: ODI, SF36-PCS/MCS, SRS-22, NRS back/leg. Among patients with 5-year follow-up, comparisons were made from both baseline and 2-years postoperative to 5-years postoperative. PROs were analyzed using mixed models for repeated measures.
UNASSIGNED: Seventy-seven patients (28.3%) had 5-year follow-up data. Comparing baseline to 5-year data among these 77 patients, significant improvement was seen in all PROs: ODI (45.2 vs. 29.3, P < 0.001), SF36-PCS (31.5 vs. 38.8, P < 0.001), SF36-MCS (44.9 vs. 49.1, P = 0.009), SRS-22-total (2.78 vs. 3.61, P < 0.001), NRS-back pain (5.70 vs. 2.95, P < 0.001) and NRS leg pain (3.64 vs. 2.62, P = 0.017). In the 2 to 5-year follow-up period, no significant changes were seen in any PROs. The percentage of patients achieving MCID from baseline to 5-years were: ODI (62.0%) and the SRS-22r domains of function (70.4%), pain (63.0%), mental health (37.5%), self-image (60.3%), and total (60.3%). Surprisingly, mean values (P > 0.05) and proportion achieving MCID did not differ significantly in patients with major surgery-related complications compared to those without.
UNASSIGNED: After complex ASD surgery, significant improvement in PROs were seen at 5-years postoperative in ODI, SF36-PCS/MCS, SRS-22r, and NRS-back/leg pain. No significant changes in PROs occurred during the 2 to 5-year postoperative period. Those with major surgery-related complications had similar PROs and proportion of patients achieving MCID as those without these complications.
摘要：
■前瞻性队列。
■前瞻性评估复杂ASD手术后长达5年的PRO。
Scoli-RISK-1研究纳入了来自15个中心的272名接受手术的ASD患者。纳入标准为Cobb角>80°,先天性或翻修畸形的矫正截骨术，和/或3柱截骨术。在术后5年的间隔内前瞻性地测量了以下PRO：ODI，SF36-PCS/MCS,SRS-22，NRS背部/腿。在5年随访的患者中，从基线和术后2年至术后5年进行比较.使用混合模型对PRO进行重复测量分析。
■77例患者（28.3%）有5年的随访数据。将这77例患者的基线数据与5年数据进行比较，在所有PRO中都看到了显着改善：ODI（45.2vs.29.3，P<0.001），SF36-PCS(31.5vs.38.8，P<0.001），SF36-MCS（44.9与49.1,P=0.009),SRS-22-总计（2.78vs.3.61，P<0.001），NRS背痛（5.70vs.2.95，P<0.001）和NRS腿部疼痛（3.64vs.2.62,P=0.017)。在2至5年的随访期内，在任何专业人员中都没有看到显著的变化。从基线到5年达到MCID的患者百分比为：ODI（62.0％）和SRS-22r功能域（70.4％），疼痛（63.0%），心理健康（37.5%），自我形象（60.3%），和总数(60.3%)。令人惊讶的是,与无手术相关并发症的患者相比,有主要手术相关并发症的患者的平均值(P>0.05)和达到MCID的比例没有显著差异.
■复杂的ASD手术后，在ODI术后5年观察到PRO的显着改善，SF36-PCS/MCS,SRS-22r,和NRS背部/腿部疼痛。在术后2至5年期间，PRO没有发生显着变化。那些有重大手术相关并发症的患者与没有这些并发症的患者具有相似的PRO和达到MCID的患者比例。
■前瞻性评估复杂ASD手术后长达5年的PRO。
Scoli-RISK-1研究纳入了来自15个中心的272名接受手术的ASD患者。纳入标准为Cobb角>80°,先天性或翻修畸形的矫正截骨术，和/或3柱截骨术。在术后5年的间隔内前瞻性地测量了以下PRO：ODI，SF36-PCS/MCS,SRS-22，NRS背部/腿。在5年随访的患者中，从基线和术后2年至术后5年进行比较.使用混合模型对PRO进行重复测量分析。
■77例患者（28.3%）有5年的随访数据。将这77例患者的基线数据与5年数据进行比较，在所有PRO中都看到了显着改善：ODI（45.2vs.29.3，P<0.001），SF36-PCS(31.5vs.38.8，P<0.001），SF36-MCS（44.9与49.1,P=0.009),SRS-22-总计（2.78vs.3.61，P<0.001），NRS背痛（5.70vs.2.95，P<0.001）和NRS腿部疼痛（3.64vs.2.62,P=0.017)。在2至5年的随访期内，在任何专业人员中都没有看到显著的变化。从基线到5年达到MCID的患者百分比为：ODI（62.0％）和SRS-22r功能域（70.4％），疼痛（63.0%），心理健康（37.5%），自我形象（60.3%），和总数(60.3%)。令人惊讶的是,与无手术相关并发症的患者相比,有主要手术相关并发症的患者的平均值(P>0.05)和达到MCID的比例没有显著差异.
■复杂的ASD手术后，在ODI术后5年观察到PRO的显着改善，SF36-PCS/MCS,SRS-22r,和NRS背部/腿部疼痛。在术后2至5年期间，PRO没有发生显着变化。那些有重大手术相关并发症的患者与没有这些并发症的患者具有相似的PRO和达到MCID的患者比例。
