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Abstract：
BACKGROUND: Transcranial direct current stimulation (tDCS) of the motor cortex (M1) produces short-term inhibition of pain. Unihemispheric concurrent dual-site tDCS (UHCDS-tDCS) over the M1 and dorsolateral prefrontal cortex (DLPFC) has greater effects on cortical excitability than when applied alone, although its effect on pain is unknown. The aim of this study was to test if anodal UHCDS-tDCS over the M1 and DLPFC in healthy participants could potentiate conditioned pain modulation (CPM) and diminish pain temporal summation (TS).
METHODS: Thirty participants were randomized to receive a sequence of UHCDS-tDCS, M1-tDCS and sham-tDCS. A 20 min 0.1 mA/cm2 anodal or sham-tDCS intervention was applied to each participant during three test sessions, according to a triple-blind cross-over trial design. For the assessment of pain processing before and after tDCS intervention, the following tests were performed: tourniquet conditioned pain modulation (CPM), pressure pain temporal summation (TS), pressure pain thresholds (PPTs), pressure pain tolerance, mechanosensitivity and cold hyperalgesia. Motor function before and after tDCS intervention was assessed with a dynamometer to measure maximal isometric grip strength.
RESULTS: No statistically significant differences were found between groups for CPM, pressure pain TS, PPT, pressure pain tolerance, neural mechanosensitivity, cold hyperalgesia or grip strength (p > 0.05).
CONCLUSIONS: Neither UHCDS-tDCS nor M1-tDCS facilitated CPM or inhibited TS in healthy subjects following one intervention session.
METHODS: Thirty participants were randomized to receive a sequence of UHCDS-tDCS, M1-tDCS and sham-tDCS. A 20 min 0.1 mA/cm2 anodal or sham-tDCS intervention was applied to each participant during three test sessions, according to a triple-blind cross-over trial design. For the assessment of pain processing before and after tDCS intervention, the following tests were performed: tourniquet conditioned pain modulation (CPM), pressure pain temporal summation (TS), pressure pain thresholds (PPTs), pressure pain tolerance, mechanosensitivity and cold hyperalgesia. Motor function before and after tDCS intervention was assessed with a dynamometer to measure maximal isometric grip strength.
RESULTS: No statistically significant differences were found between groups for CPM, pressure pain TS, PPT, pressure pain tolerance, neural mechanosensitivity, cold hyperalgesia or grip strength (p > 0.05).
CONCLUSIONS: Neither UHCDS-tDCS nor M1-tDCS facilitated CPM or inhibited TS in healthy subjects following one intervention session.
摘要：
背景：运动皮质（M1）的经颅直流电刺激（tDCS）产生对疼痛的短期抑制。M1和背外侧前额叶皮层（DLPFC）上的单半球并发双位点tDCS（UHCDS-tDCS）对皮质兴奋性的影响比单独使用时更大，虽然它对疼痛的影响是未知的。这项研究的目的是测试健康参与者中M1和DLPFC的阳极UHCDS-tDCS是否可以增强条件性疼痛调节（CPM）并减少疼痛时间总和（TS）。
方法：30名参与者随机接受一系列UHCDS-tDCS，M1-tDCS和假tDCS。在三个测试过程中，对每位参与者进行20分钟的0.1mA/cm2阳极或假tDCS干预。根据三盲交叉试验设计。为了评估tDCS干预前后的疼痛处理，进行了以下测试：止血带条件性疼痛调节（CPM），压力疼痛时间总和（TS），压力疼痛阈值（PPTs），压力疼痛耐受性，机械敏感性和冷痛觉过敏。用测力计评估tDCS干预前后的运动功能，以测量最大等距握力。
结果：CPM组间无统计学差异，压力疼痛TS，PPT,压力疼痛耐受性，神经机械敏感性，冷痛觉过敏或握力（p>0.05）。
结论：UHCDS-tDCS和M1-tDCS均未促进健康受试者在一次干预后的CPM或抑制TS。
方法：30名参与者随机接受一系列UHCDS-tDCS，M1-tDCS和假tDCS。在三个测试过程中，对每位参与者进行20分钟的0.1mA/cm2阳极或假tDCS干预。根据三盲交叉试验设计。为了评估tDCS干预前后的疼痛处理，进行了以下测试：止血带条件性疼痛调节（CPM），压力疼痛时间总和（TS），压力疼痛阈值（PPTs），压力疼痛耐受性，机械敏感性和冷痛觉过敏。用测力计评估tDCS干预前后的运动功能，以测量最大等距握力。
结果：CPM组间无统计学差异，压力疼痛TS，PPT,压力疼痛耐受性，神经机械敏感性，冷痛觉过敏或握力（p>0.05）。
结论：UHCDS-tDCS和M1-tDCS均未促进健康受试者在一次干预后的CPM或抑制TS。
