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Abstract：
Apparent comorbidity between Bipolar Disorder (BD) and Obsessive-Compulsive Disorder (OCD) is a common condition, but its meaning has not been clarified yet. The present study aimed to evaluate the pattern of occurrence of obsessive-compulsive symptoms (OCS) in the different phases of BD. One hundred and sixty-five BD patients, 62 (37.5%) euthymic, 34 (20.6%) in hypomanic/manic phase, 43 (26%) in depressive phase and 26 (15.7%) in mixed state, were assessed with the Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Hamilton Depression Rating Scale (HAM-D), the Young Mania Rating Scale (YMRS) and the Ruminative Response Scale (RRS). In the whole sample, the severity of OCS was associated to the severity of depressive symptoms. The highest severity of OCS (YBOCS total score) was observed in the mixed group and the lowest scores in the hypomanic/manic group. Our findings suggest that OCS in BD patients appear as a state-dependent phenomenon cycling with the mood phases, particularly exacerbating in the context of depressive and mixed states.
摘要：
双相障碍（BD）和强迫症（OCD）之间的明显合并症是常见的疾病，但其含义尚未明确。本研究旨在评估BD不同阶段强迫症状（OCS）的发生模式。一百六十五名BD患者，62（37.5%），34（20.6%）处于轻度躁狂/躁狂期，抑郁状态为43（26％），混合状态为26（15.7％），采用耶鲁-布朗强迫症量表(YBOCS)进行评估，汉密尔顿抑郁量表(HAM-D)，青年躁狂症评定量表(YMRS)和反思反应量表(RRS)。在整个样本中，OCS的严重程度与抑郁症状的严重程度相关.在混合组中观察到OCS的严重程度（YBOCS总分）最高，在轻度躁狂/躁狂组中得分最低。我们的发现表明，BD患者的OCS表现为一种状态依赖性现象，与情绪阶段循环，特别是在抑郁和混合状态的情况下加剧。
