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Abstract：
Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV\'s potential adjuvant activity.
摘要：
由于人口老龄化和与我们的生活方式相关的外源因素导致的病例数量不断增加，目前眼病是主要的公共卫生问题。因此，包括手术药理学方法在内的许多治疗方法已经出现，特别注意预防，在那里饮食起着重要作用。最近,潜在的抗氧化剂，如白藜芦醇，作为对抗各种眼部疾病的潜在工具，受到了很多关注。在这次审查中,我们专注于白藜芦醇抗眼部疾病的机制，特别是年龄相关性黄斑变性，青光眼,白内障,糖尿病视网膜病变，和玻璃体视网膜病变.我们分析,关于每种疾病的不同步骤，在多个层面上的白藜芦醇特性，如细胞和分子信号以及生理效应。我们展示并讨论了与活性氧的关系，炎症过程的调节，以及白藜芦醇如何通过激活sirtuin-1的潜在表观遗传作用来预防眼部疾病。最后,各种新形式的白藜芦醇给药正在出现，同时一些临床试验对白藜芦醇作为预防或治疗眼部疾病的潜在工具的未来提出了更多的疑问。需要更多的临床前研究来进一步了解RSV的潜在佐剂活性。
