关键词: ACE2, angiotensin-converting enzyme 2 ALT, alanine aminotransferase ARDS, acute respiratory distress syndrome AST, aspartate aminotransferase Acute respiratory distress syndrome (ARDS) BID, bis in die (twice a day) CCL2, chemokine C–C motif ligand 2 CCL3, chemokine C–C motif ligand 3 CCL4, chemokine C–C motif ligand 4 CCL5, chemokine C–C motif ligand 5 CCR1, C–C chemokine receptor type 1 CCR5, C–C chemokine receptor type 5 CDC, Centers for Disease Control CK, creatine kinase COPD, chronic obstructive pulmonary disease COVID-19, coronavirus disease 2019 CRP, C-reactive protein CXCL10, chemokine C-X-C motif ligand 10 CXCL2, chemokine C-X-C motif ligand 2 Coronavirus disease 2019 (COVID-19) DPP4, dipeptidyl peptidase-4 DVT, deep vein thrombosis EDTA, ethylenediaminetetraacetic acid FDA, Food and Drug Administration Fi02, fraction of inspired oxygen, IgG4 Hydroxychloroquine, HLH Leronlimab (PRO 140) Middle East respiratory syndrome coronavirus, MIG National Early Warning Score, NK RO, receptor occupancy RT–PCR, reverse transcriptase polymerase chain reaction SARS-CoV, severe acute respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 T-reg RO, regulatory T cells – receptor occupancy TGF- α, transforming growth factor alpha TNF-α, tumor necrosis factor alpha TNF-β, tumor necrosis factor beta Tregs, regulatory T cells VEGF-A, vascular endothelial growth factor A WBC, white blood cell WHO, World Health Organization eIND, emergency investigational new drug application hemophagocytic lymphohistiocytosis, HTN hypertension, ICU immunoglobulin G4, HCQ intensive care unit, IL-1β interferon gamma, IL-6 interferon gamma-inducible protein (IP) 10 or CXCL10, LOA interleukin 1 beta, IFN-ƴ interleukin 6, IP-10 letter of authorization, MCP macrophage Inflammatory Proteins 1-alpha, MIP-1β macrophage Inflammatory Proteins 1-beta, N/A macrophage colony stimulating factor, MDC (CCL22) macrophage colony-stimulating factor encoded by the CCL22 gene, MERS-CoV monocyte chemoattractant protein, M-CSF monokine induced by IFN-γ (interferon gamma), MIP-1α natural killer, OSA not applicable, NEWS2 obstructive sleep apnea, PDGF-AA per os (taken by mouth), RANTES platelet-derived growth factor AA, PDGF-AA/BB platelet-derived growth factor AA/BB, PEEP positive end-expiratory pressure, PNA pulmonary nodular amyloidosis, po regulated on activation, normal T expressed and secreted (also known as CCL5)
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DOI:10.1016/j.jtauto.2021.100083
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