前列腺素 E2 刺激 cAMP 信号并使人白血病细胞对糖皮质激素诱导的细胞死亡重新敏感。
Mesh : 1-Methyl-3-isobutylxanthine / pharmacology Animals Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cell Line, Tumor Child Chromogranins / antagonists & inhibitors Colforsin / pharmacology Cyclic AMP / pharmacology physiology Dexamethasone / administration & dosage pharmacology Dinoprostone / administration & dosage antagonists & inhibitors pharmacology physiology Drug Resistance, Neoplasm / genetics physiology Female GTP-Binding Protein alpha Subunits, Gs / antagonists & inhibitors deficiency Gene Expression Regulation, Leukemic / drug effects Humans Male Mice Models, Animal Molecular Targeted Therapy Neoplasm Proteins / biosynthesis genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy metabolism pathology RNA Interference RNA, Small Interfering / genetics pharmacology Radiation Chimera Receptors, Glucocorticoid / biosynthesis genetics physiology Receptors, Prostaglandin E, EP4 Subtype / biosynthesis genetics Second Messenger Systems / drug effects Xenograft Model Antitumor Assays
来 源:
DOI:10.1182/blood.2020005712
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