METHODS: This retrospective study included 119 cancer patients with AIS and 152 cancer patients without AIS. Basic information was collected and tumor metastasis status was determined for all patients.
RESULTS: The whole cohort had a median age of 59 (49-69) years with 150 men (55.4%). There were 98 patients (36.2%) with tumor metastasis. Patients with AIS had significantly more males, tumor metastasis, lung cancer, hypertension, diabetes mellitus, higher age, D-dimer, international normalized ratio, prothrombin time, prothrombin activity, and thrombin time, while they had significantly lower levels of hemoglobin, red blood cells, and hematocrit. In multivariate logistic regression analysis, AIS was significantly and positively associated with age, tumor metastasis, D-dimer, and thrombin time. In multivariate Cox regression analysis, tumor metastasis, AIS, D-dimer, thrombin time, and fibrinogen were significantly and positively associated with worse prognosis.
CONCLUSIONS: This study demonstrates that tumor metastasis was positively and independently associated with AIS in Chinese cancer patients, suggesting that tumor metastasis has a significant relationship with the development of AIS. Additionally, tumor metastasis and AIS had negative independent effects on the prognosis of patients.
方法:这项回顾性研究包括119名患有AIS的癌症患者和152名没有AIS的癌症患者。收集所有患者的基本信息并确定肿瘤转移状态。
结果:整个队列的中位年龄为59(49-69)岁,其中150名男性(55.4%)。有98例(36.2%)肿瘤转移。AIS患者的男性明显增多,肿瘤转移,肺癌,高血压,糖尿病,年龄较高,D-二聚体,国际标准化比率,凝血酶原时间,凝血酶原活性,和凝血酶时间,虽然他们的血红蛋白水平明显较低,红细胞,和血细胞比容.在多变量逻辑回归分析中,AIS与年龄显著正相关,肿瘤转移,D-二聚体,和凝血酶时间。在多元Cox回归分析中,肿瘤转移,AIS,D-二聚体,凝血酶时间,纤维蛋白原与不良预后呈显著正相关。
结论:这项研究表明,在中国癌症患者中,肿瘤转移与AIS呈正相关且独立相关。提示肿瘤转移与AIS的发生发展有显著关系。此外,肿瘤转移和AIS对患者的预后具有负独立影响。