在小鼠抑郁模型中, 通过 CREB 介导的成人神经发生, 鼻内治疗利西拉来减轻情绪和嗅觉症状。
关键词: CREB depression lixisenatide neurogenesis olfactory function
Mesh : Administration, Intranasal Animals Behavior, Animal / drug effects Cyclic AMP Response Element-Binding Protein / metabolism Depression / metabolism physiopathology Depressive Disorder / metabolism physiopathology Disease Models, Animal Elevated Plus Maze Test Glucagon-Like Peptide-1 Receptor / agonists Hindlimb Suspension Hippocampus / drug effects metabolism pathology Mice Neurogenesis / drug effects Olfaction Disorders / metabolism physiopathology Olfactory Bulb / drug effects metabolism pathology Open Field Test Peptides / pharmacology Stress, Psychological / metabolism physiopathology
来 源:
DOI:10.18632/aging.202358
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