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Abstract：
A high prevalence of cardiovascular risk factors including age, male sex, hypertension, diabetes, and tobacco use, has been reported in patients with Coronavirus disease 2019 (COVID-19) who experienced adverse outcome. The aim of this study was to investigate the relationship between cardiovascular risk factors and in-hospital mortality in patients with COVID-19.
MEDLINE, Cochrane, Web of Sciences, and SCOPUS were searched for retrospective or prospective observational studies reporting data on cardiovascular risk factors and in-hospital mortality in patients with COVID-19. Univariable and multivariable age-adjusted analyses were conducted to evaluate the association between cardiovascular risk factors and the occurrence of in-hospital death.
The analysis included 45 studies enrolling 18,300 patients. The pooled estimate of in-hospital mortality was 12% (95% CI 9-15%). The univariable meta-regression analysis showed a significant association between age (coefficient: 1.06; 95% CI 1.04-1.09; p < 0.001), diabetes (coefficient: 1.04; 95% CI 1.02-1.07; p < 0.001) and hypertension (coefficient: 1.01; 95% CI 1.01-1.03; p = 0.013) with in-hospital death. Male sex and smoking did not significantly affect mortality. At multivariable age-adjusted meta-regression analysis, diabetes was significantly associated with in-hospital mortality (coefficient: 1.02; 95% CI 1.01-1.05; p = 0.043); conversely, hypertension was no longer significant after adjustment for age (coefficient: 1.00; 95% CI 0.99-1.01; p = 0.820). A significant association between age and in-hospital mortality was confirmed in all multivariable models.
This meta-analysis suggests that older age and diabetes are associated with higher risk of in-hospital mortality in patients infected by SARS-CoV-2. Conversely, male sex, hypertension, and smoking did not independently correlate with fatal outcome.
MEDLINE, Cochrane, Web of Sciences, and SCOPUS were searched for retrospective or prospective observational studies reporting data on cardiovascular risk factors and in-hospital mortality in patients with COVID-19. Univariable and multivariable age-adjusted analyses were conducted to evaluate the association between cardiovascular risk factors and the occurrence of in-hospital death.
The analysis included 45 studies enrolling 18,300 patients. The pooled estimate of in-hospital mortality was 12% (95% CI 9-15%). The univariable meta-regression analysis showed a significant association between age (coefficient: 1.06; 95% CI 1.04-1.09; p < 0.001), diabetes (coefficient: 1.04; 95% CI 1.02-1.07; p < 0.001) and hypertension (coefficient: 1.01; 95% CI 1.01-1.03; p = 0.013) with in-hospital death. Male sex and smoking did not significantly affect mortality. At multivariable age-adjusted meta-regression analysis, diabetes was significantly associated with in-hospital mortality (coefficient: 1.02; 95% CI 1.01-1.05; p = 0.043); conversely, hypertension was no longer significant after adjustment for age (coefficient: 1.00; 95% CI 0.99-1.01; p = 0.820). A significant association between age and in-hospital mortality was confirmed in all multivariable models.
This meta-analysis suggests that older age and diabetes are associated with higher risk of in-hospital mortality in patients infected by SARS-CoV-2. Conversely, male sex, hypertension, and smoking did not independently correlate with fatal outcome.
摘要：
心血管危险因素的高患病率，包括年龄，男性,高血压,糖尿病,和烟草的使用，据报道，2019年冠状病毒疾病（COVID-19）患者出现不良结局。这项研究的目的是调查心血管危险因素与COVID-19患者院内死亡率之间的关系。
MEDLINE,科克伦,WebofSciences,和SCOPUS进行了回顾性或前瞻性观察研究,这些研究报告了COVID-19患者心血管危险因素和院内死亡率的数据.进行了单变量和多变量年龄校正分析，以评估心血管危险因素与住院死亡发生之间的关联。
该分析包括45项研究，招募18,300名患者。住院死亡率的汇总估计值为12％（95％CI9-15％）。单变量荟萃回归分析显示年龄之间存在显着关联（系数：1.06;95％CI1.04-1.09;p<0.001），糖尿病（系数：1.04;95%CI1.02-1.07;p<0.001）和高血压（系数：1.01;95%CI1.01-1.03;p=0.013）与住院死亡。男性和吸烟对死亡率没有显著影响。在多变量年龄调整后的荟萃回归分析中，糖尿病与住院死亡率显著相关(系数:1.02;95%CI1.01-1.05;p=0.043);相反,校正年龄后,高血压不再显著(系数:1.00;95%CI0.99-1.01;p=0.820).在所有多变量模型中都证实了年龄和住院死亡率之间的显著关联。
这项荟萃分析提示，在感染SARS-CoV-2的患者中，高龄和糖尿病与院内死亡风险较高相关。相反，男性,高血压,吸烟与致死性结局无独立相关性.
MEDLINE,科克伦,WebofSciences,和SCOPUS进行了回顾性或前瞻性观察研究,这些研究报告了COVID-19患者心血管危险因素和院内死亡率的数据.进行了单变量和多变量年龄校正分析，以评估心血管危险因素与住院死亡发生之间的关联。
该分析包括45项研究，招募18,300名患者。住院死亡率的汇总估计值为12％（95％CI9-15％）。单变量荟萃回归分析显示年龄之间存在显着关联（系数：1.06;95％CI1.04-1.09;p<0.001），糖尿病（系数：1.04;95%CI1.02-1.07;p<0.001）和高血压（系数：1.01;95%CI1.01-1.03;p=0.013）与住院死亡。男性和吸烟对死亡率没有显著影响。在多变量年龄调整后的荟萃回归分析中，糖尿病与住院死亡率显著相关(系数:1.02;95%CI1.01-1.05;p=0.043);相反,校正年龄后,高血压不再显著(系数:1.00;95%CI0.99-1.01;p=0.820).在所有多变量模型中都证实了年龄和住院死亡率之间的显著关联。
这项荟萃分析提示，在感染SARS-CoV-2的患者中，高龄和糖尿病与院内死亡风险较高相关。相反，男性,高血压,吸烟与致死性结局无独立相关性.
