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Abstract：
This study aimed to evaluate the effectiveness of physical activity (PA) interrupting prolonged sitting (PS) on postprandial glycemia and insulin responses among adults.
PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, PsycINFO, and the China National Knowledge Infrastructure databases were searched through September 30, 2020. Randomized controlled trials (RCTs) that examined the effect of all forms of PA interrupting PS on postprandial glycemia and/or insulin responses among adults without chronic diseases were included in this study. The risk of bias of included studies was evaluated based on the Cochrane tool. A network meta-analysis was performed to estimate the summary standardized mean differences (SMDs) with 95% confidence intervals (95%CIs) with random effects.
Thirty crossover RCTs were included in our review. These RCTs included 9 types of interventions that interrupted PS. When compared to PS by itself, light-intensity PA intermittent interrupting (LPA-INT) PS and moderate-intensity PA intermittent interrupting (MPA-INT) PS significantly lowered postprandial glycemia (SMD = -0.46, 95%CI: -0.70 to -0.21; SMD = -0.69, 95%CI: -1.00 to -0.37, respectively) and significantly reduced postprandial insulin response (SMD = -0.46, 95%CI: -0.66 to -0.26; SMD = -0.47, 95%CI: -0.77 to -0.17, respectively). Results of the clustered ranking plot indicated that MPA-INT was the most effective intervention in lowering postprandial glycemia and insulin responses.
Replacing PS with MPA-INT or LPA-INT has a positive effect in reducing postprandial glycemia and insulin responses, with MPA-INT being the optimal intervention strategy.
PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, PsycINFO, and the China National Knowledge Infrastructure databases were searched through September 30, 2020. Randomized controlled trials (RCTs) that examined the effect of all forms of PA interrupting PS on postprandial glycemia and/or insulin responses among adults without chronic diseases were included in this study. The risk of bias of included studies was evaluated based on the Cochrane tool. A network meta-analysis was performed to estimate the summary standardized mean differences (SMDs) with 95% confidence intervals (95%CIs) with random effects.
Thirty crossover RCTs were included in our review. These RCTs included 9 types of interventions that interrupted PS. When compared to PS by itself, light-intensity PA intermittent interrupting (LPA-INT) PS and moderate-intensity PA intermittent interrupting (MPA-INT) PS significantly lowered postprandial glycemia (SMD = -0.46, 95%CI: -0.70 to -0.21; SMD = -0.69, 95%CI: -1.00 to -0.37, respectively) and significantly reduced postprandial insulin response (SMD = -0.46, 95%CI: -0.66 to -0.26; SMD = -0.47, 95%CI: -0.77 to -0.17, respectively). Results of the clustered ranking plot indicated that MPA-INT was the most effective intervention in lowering postprandial glycemia and insulin responses.
Replacing PS with MPA-INT or LPA-INT has a positive effect in reducing postprandial glycemia and insulin responses, with MPA-INT being the optimal intervention strategy.
摘要：
这项研究旨在评估成年人体力活动（PA）中断长时间坐着（PS）对餐后血糖和胰岛素反应的有效性。
PubMed,EMBASE,科克伦图书馆,WebofScience,CINAHL,PsycINFO,并在2020年9月30日之前搜索了中国国家知识基础设施数据库。这项研究包括随机对照试验（RCT），该试验检查了所有形式的PA中断PS对无慢性疾病的成年人餐后血糖和/或胰岛素反应的影响。基于Cochrane工具评估纳入研究的偏倚风险。进行了网络荟萃分析，以95％置信区间（95CIs）估算具有随机效应的汇总标准化平均差（SMD）。
我们的综述中包括了30个交叉随机对照试验。这些随机对照试验包括9种中断PS的干预措施。与PS本身相比，光强度PA间歇性中断（LPA-INT）PS和中等强度PA间歇性中断（MPA-INT）PS显着降低餐后血糖（SMD=-0.46，95CI：-0.70至-0.21；SMD=-0.69，95CI：-1.00至-0.37），显着降低餐后胰岛素反应（SMD=-0.46，95CI：-0.66-0.26）；SMCI-聚类排序图的结果表明，MPA-INT是降低餐后血糖和胰岛素反应的最有效干预措施。
用MPA-INT或LPA-INT替代PS在降低餐后血糖和胰岛素反应方面具有积极作用。MPA-INT是最佳干预策略。
PubMed,EMBASE,科克伦图书馆,WebofScience,CINAHL,PsycINFO,并在2020年9月30日之前搜索了中国国家知识基础设施数据库。这项研究包括随机对照试验（RCT），该试验检查了所有形式的PA中断PS对无慢性疾病的成年人餐后血糖和/或胰岛素反应的影响。基于Cochrane工具评估纳入研究的偏倚风险。进行了网络荟萃分析，以95％置信区间（95CIs）估算具有随机效应的汇总标准化平均差（SMD）。
我们的综述中包括了30个交叉随机对照试验。这些随机对照试验包括9种中断PS的干预措施。与PS本身相比，光强度PA间歇性中断（LPA-INT）PS和中等强度PA间歇性中断（MPA-INT）PS显着降低餐后血糖（SMD=-0.46，95CI：-0.70至-0.21；SMD=-0.69，95CI：-1.00至-0.37），显着降低餐后胰岛素反应（SMD=-0.46，95CI：-0.66-0.26）；SMCI-聚类排序图的结果表明，MPA-INT是降低餐后血糖和胰岛素反应的最有效干预措施。
用MPA-INT或LPA-INT替代PS在降低餐后血糖和胰岛素反应方面具有积极作用。MPA-INT是最佳干预策略。
