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Abstract：
A case-control study was conducted to investigate the relationship between indoor air pollution and childhood acute leukemia (AL) in Shanghai. 97 cases and 148 gender-, age-, and residence-matched controls were included. Indoor air pollution was evaluated by questionnaires and quantitative measurement including 14 volatile organic compounds (VOCs) and nitrogen dioxide (NO2) in the homes of the two groups. The levels of individual VOCs, VOC families, TVOC (sum of the concentrations of the individual VOCs) and NO2 were compared between the two groups. Exposure to styrene and butyl alcohol were associated with an increased risk of childhood AL (styrene: odds ratio (OR)=2.33, 95% confidence interval (CI): 1.07-5.07; butyl alcohol: OR = 2.51, 95%CI: 1.19-5.28); 4th quartile of chlorinated hydrocarbons (OR = 2.52, 95%CI: 1.02-6.26) and 3rd quartile of TVOC (OR = 4.03, 95%CI: 1.06-6.81) had significant higher ORs for childhood AL compared with that in the lowest quartiles. Elevated levels of individual VOCs, VOC families and TVOC were also associated with self-reported risk factors. Our findings suggest that VOCs exposure was associated with an elevated risk of childhood AL, underscore that more attention should be paid to indoor air pollution as a risk factor of childhood AL.
摘要：
采用病例对照研究方法,探讨上海地区室内空气污染与儿童急性白血病(AL)的关系。97例和148个性别-，年龄-,和居住匹配的对照包括在内。通过问卷调查和定量测量评估了两组家庭中的14种挥发性有机化合物（VOCs）和二氧化氮（NO2）。个别挥发性有机化合物的水平，VOC家族,比较两组TVOC（各VOCs浓度的总和）和NO2。暴露于苯乙烯和丁醇与儿童期AL的风险增加相关（苯乙烯：比值比（OR）=2.33，95％置信区间（CI）：1.07-5.07；丁醇：OR=2.51，95CI：1.19-5.28）；氯化烃的第4四分位数（OR=2.52，95CI：1.02-6.26）和TVOC的第3四分位数（OR=4.03，显著）在儿童期的1.06个别挥发性有机化合物的水平升高，VOC家族和TVOC也与自我报告的危险因素有关。我们的研究结果表明，VOCs暴露与儿童AL的风险升高有关，强调应将室内空气污染作为儿童AL的危险因素给予更多关注。
