Primary cutaneous malignant melanoma in Rett syndrome: Report of a case with nuclear features resembling herpes simplex virus cytopathic effects-a hitherto unrecognized morphological variant.

Rett 综合征中的原发性皮肤恶性黑色素瘤 ： 一例具有类似于单纯疱疹病毒细胞病变作用的核特征的病例的报告 - 迄今为止尚未识别的形态学变体。

• 影响指数: 1.458
• 发表时间: Jul 2021
• 来源期刊: J Cutan Pathol
• DOI: 10.1111/cup.13943
• PMID: 33345376
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Petkar MA,Rodrigo T

关键词: MECP2; Rett syndrome; herpes simplex virus cytopathic effects; malignant melanoma

Mesh: Adult; Cytopathogenic Effect, Viral / genetics; Disease Progression; Female; Humans; Melanoma / diagnosis metabolism pathology surgery; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Rett Syndrome / complications genetics pathology; Simplexvirus / metabolism; Skin Neoplasms / diagnosis metabolism pathology surgery; Melanoma, Cutaneous Malignant

Abstract

Rett syndrome (RTT) is a progressive neurological disorder, affecting females with mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). While MECP2 has been implicated in cancers of the breast, colon, and prostrate, cancer in patients with RTT is rare. We present a case of malignant melanoma in a patient with RTT, which additionally, displayed hitherto undescribed nuclear features, resembling herpes simplex virus cytopathic effects.

摘要

Rett综合征（RTT）是一种进行性神经系统疾病，影响X连锁基因甲基-CpG结合蛋白2（MECP2）突变的女性。虽然MECP2与乳腺癌有关，结肠,俯卧，RTT患者的癌症很少见。我们介绍了一例RTT患者的恶性黑色素瘤，此外，展示了迄今未描述的核特征，类似于单纯疱疹病毒的细胞病变效应。