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Abstract：
The extent to which walking pace is associated with a reduced risk for stroke remains unclear. This study examined the association between walking pace and stroke risk based on prospective cohort studies.
Databases of PubMed, EMBASE, Web of Science, Scopus, and China National Knowledge Internet were searched from the inception dates to January 31, 2019, for prospective cohort studies focusing on walking pace and risk of stroke in adults. Two reviewers independently extracted data and assessed the quality of the studies. The dependent measure was stroke incidence. Using random-effects models, a meta-analysis was performed to estimate the overall relative risks (RR) of stroke incidence and 95% confidence intervals (CIs) for the individuals with the fastest walking paces vs. individuals with the slowest walking paces. A dose-response relationship was also examined.
After screening 1294 titles/abstracts and 14 full-text studies identified in the search, 7 studies (from 8 cohorts) were included in the meta-analysis. The 7 studies included a total of 135,645 participants (95.2% women; mean age 63.6 years) and 2229 stroke events (median follow-up time = 8.0 years). Compared to individuals in the slowest walking-pace category (median = 1.6 km/h), individuals in the fastest walking-pace category (median = 5.6 km/h) had a 44% lower risk of stroke (pooled RR = 0.56, 95%CI: 0.48-0.65). There was also a linear dose-response relationship (RR = 0.87; 95%CI: 0.83-0.91), with the risk of stroke decreased by 13% for every 1 km/h increment in baseline walking pace. We observed similar results across walking-pace assessment, type of stroke ascertainment, stroke subtypes, sex, sample size, and duration of follow-up.
Findings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke.
Databases of PubMed, EMBASE, Web of Science, Scopus, and China National Knowledge Internet were searched from the inception dates to January 31, 2019, for prospective cohort studies focusing on walking pace and risk of stroke in adults. Two reviewers independently extracted data and assessed the quality of the studies. The dependent measure was stroke incidence. Using random-effects models, a meta-analysis was performed to estimate the overall relative risks (RR) of stroke incidence and 95% confidence intervals (CIs) for the individuals with the fastest walking paces vs. individuals with the slowest walking paces. A dose-response relationship was also examined.
After screening 1294 titles/abstracts and 14 full-text studies identified in the search, 7 studies (from 8 cohorts) were included in the meta-analysis. The 7 studies included a total of 135,645 participants (95.2% women; mean age 63.6 years) and 2229 stroke events (median follow-up time = 8.0 years). Compared to individuals in the slowest walking-pace category (median = 1.6 km/h), individuals in the fastest walking-pace category (median = 5.6 km/h) had a 44% lower risk of stroke (pooled RR = 0.56, 95%CI: 0.48-0.65). There was also a linear dose-response relationship (RR = 0.87; 95%CI: 0.83-0.91), with the risk of stroke decreased by 13% for every 1 km/h increment in baseline walking pace. We observed similar results across walking-pace assessment, type of stroke ascertainment, stroke subtypes, sex, sample size, and duration of follow-up.
Findings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke.
摘要：
步行速度与中风风险降低的程度尚不清楚。这项研究基于前瞻性队列研究检查了步行速度与卒中风险之间的关系。
PubMed的数据库，EMBASE,WebofScience,Scopus,本研究从开始日期至2019年1月31日,对中国国家知识互联网进行了前瞻性队列研究,重点关注成人步行速度和卒中风险.两名评审员独立提取数据并评估研究质量。依赖性测量是中风发生率。使用随机效应模型，进行了荟萃分析，以估计步行速度最快的个体与中风发生率的总体相对风险（RR）和95％置信区间（CI）。步行速度最慢的人。还检查了剂量-反应关系。
在筛选了搜索中确定的1294篇标题/摘要和14篇全文研究之后，7项研究（来自8个队列）被纳入荟萃分析。7项研究共纳入135,645名参与者（95.2%为女性；平均年龄63.6岁）和2229例卒中事件（中位随访时间=8.0年）。与步行速度最慢的人相比（中位数=1.6km/h），步行速度最快类别(中位数=5.6km/h)的个体卒中风险降低44%(合并RR=0.56,95CI:0.48~0.65).还存在线性剂量反应关系（RR=0.87；95CI：0.83-0.91），基线步行步速每增加1km/h，卒中风险降低13%。我们在步行速度评估中观察到类似的结果，中风类型确定，中风亚型，性别,样本量,和随访时间。
这项荟萃分析的结果表明，步行速度与卒中风险呈负相关。
PubMed的数据库，EMBASE,WebofScience,Scopus,本研究从开始日期至2019年1月31日,对中国国家知识互联网进行了前瞻性队列研究,重点关注成人步行速度和卒中风险.两名评审员独立提取数据并评估研究质量。依赖性测量是中风发生率。使用随机效应模型，进行了荟萃分析，以估计步行速度最快的个体与中风发生率的总体相对风险（RR）和95％置信区间（CI）。步行速度最慢的人。还检查了剂量-反应关系。
在筛选了搜索中确定的1294篇标题/摘要和14篇全文研究之后，7项研究（来自8个队列）被纳入荟萃分析。7项研究共纳入135,645名参与者（95.2%为女性；平均年龄63.6岁）和2229例卒中事件（中位随访时间=8.0年）。与步行速度最慢的人相比（中位数=1.6km/h），步行速度最快类别(中位数=5.6km/h)的个体卒中风险降低44%(合并RR=0.56,95CI:0.48~0.65).还存在线性剂量反应关系（RR=0.87；95CI：0.83-0.91），基线步行步速每增加1km/h，卒中风险降低13%。我们在步行速度评估中观察到类似的结果，中风类型确定，中风亚型，性别,样本量,和随访时间。
这项荟萃分析的结果表明，步行速度与卒中风险呈负相关。
