METHODS: Data from 10 patients (mean age: 70.4; m: 6; f: 4) with coronary heart disease who underwent IVUS, OCT, and angiography were collected at Cardiovascular Research Foundation (CRF) using approved protocol with informed consent obtained. 348 slices with lipid core and fibrous caps were selected for study. Convolutional Neural Network (CNN)-based and expert-based data segmentation were performed using established methods previously published. Cap thickness data were extracted to quantify differences between IVUS and OCT measurements.
RESULTS: For the 348 slices analyzed, the mean value difference between OCT and IVUS cap thickness measurements was 1.83% (p = 0.031). However, mean value of point-to-point differences was 35.76%. Comparing minimum cap thickness for each plaque, the mean value of the 20 plaque IVUS-OCT differences was 44.46%, ranging from 2.36% to 91.15%. For cap index values assigned to the 348 slices, the disagreement between OCT and IVUS assignments was 25%. However, for the OCT cap index = 2 and 3 groups, the disagreement rates were 91% and 80%, respectively. Furthermore, the observation of cap index changes from baseline to follow-up indicated that IVUS results differed from OCT by 80%.
CONCLUSIONS: These preliminary results demonstrated that there were significant differences between IVUS and OCT plaque cap thickness measurements. Large-scale patient studies are needed to confirm our findings.
方法:数据来自10例接受IVUS的冠心病患者(平均年龄:70.4;m:6;f:4),OCT,在获得知情同意的情况下,在心血管研究基金会(CRF)使用批准的方案收集血管造影.选择具有脂质核心和纤维帽的348个切片用于研究。基于卷积神经网络(CNN)和基于专家的数据分割是使用先前发布的已建立的方法进行的。提取帽厚度数据以量化IVUS和OCT测量之间的差异。
结果:对于分析的348个切片,OCT和IVUS帽厚度测量的平均值差异为1.83%(p=0.031).然而,点对点差异的平均值为35.76%.比较每个板的最小盖厚度,20个斑块IVUS-OCT差异的平均值为44.46%,范围从2.36%到91.15%。对于分配给348个切片的cap索引值,OCT和IVUS分配的差异为25%.然而,对于OCT帽指数=2和3组,分歧率为91%和80%,分别。此外,从基线到随访的cap指数变化观察表明,IVUS结果与OCT相比有80%的差异.
结论:这些初步结果表明IVUS和OCT斑块盖厚度测量之间存在显著差异。需要大规模的患者研究来证实我们的发现。