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Abstract：
Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implant-associated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.
摘要：
由于独特的物理，化学,机械和电气性能，自过去十年以来，石墨烯及其衍生物已被广泛研究用于各种生物医学应用，包括组织工程。氧化石墨烯（GO）的可调谐化学官能团，石墨烯衍生物，允许容易的表面功能化。GO与聚乙二醇(PEG)(PEG-GO)的官能化已经受到了极大的关注,因为它提供了优越的溶解性,稳定性,和生物相容性。除了是一个有吸引力的药物输送候选人，PEG-GO可以帮助附着，扩散,和干细胞的分化，从而增强组织工程。PEG-GO已显示出优异的抗菌功效，这可能是减少植入物相关感染的额外优势。这篇综述描述了合成技术，属性,以及PEG-GO对哺乳动物和细菌细胞的生物潜力。这些纳米材料已被探索用于工程各种组织的研究以及该领域的未来机会进行了回顾。
