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Abstract：
This study aimed to evaluate the performance of the point-of-care circulating cathodic antigen (POC-CCA) test in a highly endemic area in Brazil, comparing it to the Kato-Katz (KK) technique for sensitivity, specificity and the intensity of the reaction of the test in relation to the parasitic load. The community in Sergipe, Brazil, participated in the study, providing three stool samples, one of urine (POC-CCA) and fingers tick blood sample was tested by enzyme-linked immunosorbent assay (ELISA). Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, kappa coefficient and Spearman\'s correlation were calculated for the POC-CCA test using the KK as the reference. The prevalence of schistosomiasis by KK testing was 48.82%; POC-CCA (t+) 66.14%; POC-CCA (t-) 45.24%. ELISA results showed 100% agreement in individuals with high and moderate eggs per gram (EPG). POC-CCA presented good diagnostic performance in individuals with medium and high EPG, but there were a high number of false negatives in individuals with low intensity infections. As observed, POC-CCA-filter test improves accuracy and sensitivity compared to a conventional test.
摘要：
本研究旨在评估巴西高流行地区的即时循环阴极抗原（POC-CCA）测试的性能，将其与加藤-卡茨(KK)技术进行灵敏度比较，特异性和与寄生负荷相关的测试反应强度。Sergipe的社区,巴西,参与研究,提供三个粪便样本，用酶联免疫吸附试验(ELISA)检测尿液(POC-CCA)和手指蜱血样中的一种。灵敏度,特异性，正预测值，负预测值，准确度,使用KK作为参考，计算POC-CCA检验的κ系数和Spearman相关性。通过KK检测，血吸虫病的患病率为48.82％；POC-CCA（t）为66.14％；POC-CCA（t-）为45.24％。ELISA结果显示，每克鸡蛋（EPG）高和中等的个体具有100％的一致性。POC-CCA在中高EPG患者中表现出良好的诊断性能，但是在低强度感染的个体中存在大量的假阴性。正如观察到的，与常规测试相比,POC-CCA-滤波器测试提高了准确度和灵敏度。
