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Abstract：
The analysis of the effects of autozygosity, measured as the change of the mean value of a trait among offspring of genetic relatives, reveals the existence of directional dominance or overdominance. In this study we detect evidence of the effect of autozygosity in 4 out of 13 cardiometabolic disease-associated traits using data from more than 10,000 sub-Saharan African individuals recruited from Ghana, Burkina Faso, Kenya and South Africa. The effect of autozygosity on these phenotypes is found to be sex-related, with inbreeding having a significant decreasing effect in men but a significant increasing effect in women for several traits (body mass index, subcutaneous adipose tissue, low-density lipoproteins and total cholesterol levels). Overall, the effect of inbreeding depression is more intense in men. Differential effects of inbreeding depression are also observed between study sites with different night-light intensity used as proxy for urban development. These results suggest a directional dominant genetic component mediated by environmental interactions and sex-specific differences in genetic architecture for these traits in the Africa Wits-INDEPTH partnership for Genomic Studies (AWI-Gen) cohort.
摘要：
自合性效应的分析，以遗传亲属后代中性状平均值的变化来衡量，揭示了方向优势或过度优势的存在。在这项研究中，我们使用来自加纳招募的10,000多名撒哈拉以南非洲个体的数据，检测了13种心脏代谢疾病相关性状中4种的自合性效应的证据。布基纳法索,肯尼亚和南非。发现自合性对这些表型的影响与性别有关，近亲繁殖在男性中具有显着降低的作用，但在女性中对几种性状具有显着增加的作用（体重指数，皮下脂肪组织，低密度脂蛋白和总胆固醇水平）。总的来说,近亲繁殖抑郁症的影响在男性中更为强烈。在具有不同夜光强度的研究地点之间，也观察到近亲繁殖抑郁症的不同影响，这些研究地点用作城市发展的代表。这些结果表明，在非洲Wits-INDEPTH基因组研究伙伴关系（AWI-Gen）队列中，环境相互作用和这些性状的遗传结构中的性别特异性差异介导了定向显性遗传成分。
