PFA 室管膜瘤中 CXorf67 表达升高抑制 DNA 修复并对 PARP 抑制剂敏感。
关键词: CXorf67 PALB2 PARP inhibitors ependymoma tumor homologous recombination repair radiotherapy
Mesh : Animals BRCA2 Protein / metabolism Cell Line, Tumor Cell Proliferation / drug effects radiation effects Cell Survival / drug effects radiation effects Chemoradiotherapy Ependymoma / genetics metabolism therapy Fanconi Anemia Complementation Group N Protein / metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic / drug effects radiation effects Humans Infratentorial Neoplasms / genetics metabolism therapy Mice Oligonucleotide Array Sequence Analysis Oncogene Proteins / genetics metabolism Poly(ADP-ribose) Polymerase Inhibitors / administration & dosage pharmacology Recombinational DNA Repair / drug effects radiation effects Up-Regulation Xenograft Model Antitumor Assays
来 源:
DOI:10.1016/j.ccell.2020.10.009
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