关键词: FGF1 GDF-15 MMPs PTEN TIMP1 docetaxel prostate cancer metastasis senescence senescence-associated secretory phenotype (SASP) senolytic therapy
Mesh : Animals Cellular Senescence / drug effects Docetaxel / administration & dosage pharmacology Gene Deletion Gene Expression Regulation, Neoplastic Humans Male Matrix Metalloproteinases / metabolism Mice Neoplasm Metastasis Neoplasm Transplantation PC-3 Cells PTEN Phosphohydrolase / genetics Prostatic Neoplasms / drug therapy genetics metabolism pathology Tissue Inhibitor of Metalloproteinase-1 / genetics
来 源:
DOI:10.1016/j.ccell.2020.10.012
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