Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents.

关于在儿童和青少年鱼鳞病和其他角质化疾病中使用类维生素 A 的共识建议。

• 影响指数: 1.997
• 发表时间: Jan 2021
• 来源期刊: Pediatr Dermatol
• DOI: 10.1111/pde.14408
• PMID: 33169909
• 文章类型: Journal Article
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Zaenglein AL,Levy ML,Stefanko NS,Benjamin LT,Bruckner AL,Choate K,Craiglow BG,DiGiovanna JJ,Eichenfield LF,Elias P,Fleckman P,Lawley LP,Lewis RA,Lucky AW,Mathes EF,Milstone LM,Paller AS,Patel SS,Siegel DH,Teng J,Tanumihardjo SA,Thaxton L,Williams ML,

关键词: adverse drug effects; bone health; contraception; depression; disorder of cornification; drug monitoring; ectropion; hyperlipidemia; iPLEDGE; ichthyosis; quality of life; retinoid; safety monitoring; systemic therapy; topical therapy

Mesh: Adolescent; Child; Consensus; Humans; Ichthyosis / drug therapy; Ichthyosis, Lamellar; Retinoids

Abstract

Topical and systemic retinoids have long been used in the treatment of ichthyoses and other disorders of cornification. Due to the need for long-term use of retinoids for these disorders, often beginning in childhood, numerous clinical concerns must be considered. Systemic retinoids have known side effects involving bone and eye. Additionally, potential psychiatric and cardiovascular effects need to be considered. Contraceptive concerns, as well as the additive cardiovascular and bone effects of systemic retinoid use with hormonal contraception must also be deliberated for patients of childbearing potential. The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoids in Ichthyosis Work Group was formed to address these issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.

摘要

局部和全身性类维生素A长期用于治疗鱼鳞病和其他角质化病症。由于需要长期使用类维生素A治疗这些疾病，通常从童年开始，必须考虑许多临床问题。系统性类维生素A具有涉及骨骼和眼睛的已知副作用。此外,需要考虑潜在的精神和心血管影响.避孕问题，对于有生育潜力的患者，还必须考虑全身使用类维生素A与激素避孕的附加心血管和骨骼效应。成立了儿科皮肤病研究联盟（PeDRA）在鱼鳞病中使用类维生素A工作组，以解决这些问题，并根据现有证据和专家意见建立有关在鱼鳞病中使用类维生素A的最佳实践。