药物发现范式中的蛋白水解靶向嵌合体 ( PROTAC ) : 最新进展和未来挑战。
关键词: Drug discovery Drug resistance PROTAC Small molecule Target protein degradation Undruggable target
Mesh : Dose-Response Relationship, Drug Drug Discovery Humans Molecular Structure Proteolysis / drug effects Receptors, Androgen / metabolism Small Molecule Libraries / chemistry pharmacology Structure-Activity Relationship
来 源:
DOI:10.1016/j.ejmech.2020.112981
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