METHODS: Retrospective case control study. The clinical data of symptomatic cCMV and asymptomatic cCMV patients were collected and compared to those of Cx26 patients matched for age and pre-CI (cochlear implant) linguistic category; all subjects were affected by bilateral severe-to-profound SNHL and were treated by CI and speech therapy rehabilitation. The Speech Perception Category, the language stage and the linguistic level scores, at 6 months, 1 year, and 3-4 years after CI of the three groups (symptomatic cCMV, asymptomatic cCMV and Cx26 mutation) were collected and compared.
RESULTS: Statistical analysis did not show any significant difference in pre-CI perception category and linguistic level among the three groups; the symptomatic cCMV group showed a statistically worse performance of the language stage over time (p = 0.017).
CONCLUSIONS: Our data support that children affected by cCMV have improved language abilities over time, although the symptomatic cCMV group achieved a lower language stage 3-4 years after CI compared to the asymptomatic cCMV and Cx26 mutation groups. Nonetheless, to date, CI supported by speech therapy can be considered an effective intervention for children affected by cCMV-related severe-to-profound hearing loss.
方法:回顾性病例对照研究。收集有症状的cCMV和无症状的cCMV患者的临床数据,并将其与年龄和CI前(人工耳蜗植入)语言类别相匹配的Cx26患者的临床数据进行比较;所有受试者均受到双侧严重至严重的SNHL的影响,并接受CI和言语治疗康复治疗。语音感知类别,语言阶段和语言水平分数,6个月时,1年,和三组的CI后3-4年(症状性cCMV,收集并比较无症状的cCMV和Cx26突变)。
结果:统计学分析显示三组在CI前感知类别和语言水平上没有任何显著差异;有症状的cCMV组显示出语言阶段随时间的统计学表现较差(p=0.017)。
结论:我们的数据支持受cCMV影响的儿童随着时间的推移语言能力得到改善,尽管与无症状cCMV和Cx26突变组相比,有症状cCMV组在CI后3-4年实现了较低的语言阶段.尽管如此,到目前为止,言语治疗支持的CI可被认为是受cCMV相关严重至深度听力损失影响的儿童的有效干预措施。