Clinical course of COVID-19 among immunocompromised children: a clinical case series.

免疫功能低下儿童中 COVID - 19 的临床病程 ： 临床病例系列。

• 发表时间: Oct 2020 31
• 来源期刊: BMJ Case Rep
• DOI: 10.1136/bcr-2020-237804
• PMID: 33130585
• 文章类型: Journal Article
• 作者列表: El Dannan H,Al Hassani M,Ramsi M

关键词: immunology; infectious diseases; paediatrics

Mesh: Age Factors; COVID-19; Child; Child, Preschool; Combined Modality Therapy; Coronavirus Infections / diagnosis epidemiology therapy; Female; Humans; Immunocompromised Host / immunology; Male; Pandemics / prevention & control statistics & numerical data; Pneumonia, Viral / diagnosis epidemiology therapy; Prognosis; Risk Assessment; Sampling Studies; Severe Acute Respiratory Syndrome / diagnosis epidemiology therapy; Severity of Illness Index; Sex Factors; Treatment Outcome

Abstract

Infection with SARS-CoV-2 represents a great source of concern and a new threat for immunocompromised patients. Limited studies are available on COVID-19 in immunocompromised children. This case series aimed to evaluate the clinical and laboratory characteristics, management and outcomes of COVID-19 in five children immunocompromised due to different underlying conditions. All had mild symptoms or were asymptomatic at presentation. All had a benign course of illness. No changes or delays in their treatment regimens occurred, and none experienced a relapse of the original disease, developed severe COVID-19 or died. However, these cases showed a prolonged duration of virus shedding. This report suggests that immunocompromised paediatric patients may not be at a higher risk of developing severe COVID-19. However, further studies are required to elaborate on the pathogenesis of COVID-19 in this vulnerable group.

摘要

SARS-CoV-2感染对免疫功能低下的患者来说是一个很大的问题和新的威胁。关于COVID-19在免疫受损儿童中的研究有限。本病例系列旨在评估临床和实验室特征，5名因不同基础条件而免疫受损的儿童COVID-19的治疗和结局。所有患者均有轻度症状或无症状。所有人都患有良性疾病。他们的治疗方案没有改变或延误，没有人经历过原始疾病的复发，发展为严重的COVID-19或死亡。然而,这些病例显示病毒脱落持续时间延长。该报告表明，免疫功能低下的儿科患者可能不会有更高的患严重COVID-19的风险。然而,COVID-19在该易感人群中的发病机制有待进一步研究。