PDF(Sci-hub)
Abstract：
The prevalence of multiple sclerosis (MS) in Asian countries is thought to be lower than in Western countries, with Asian populations presenting 80% less risk of MS than white populations. Incidence and prevalence rates in Asian countries are therefore not well defined and their association with rates in neighboring countries, as well as with ethnic, environmental, and socioeconomic factors, are not well understood. We performed a comprehensive literature review of epidemiological data from China and neighbouring countries to study the frequency of the disease, focusing on prevalence, and the progression over time and the influence of sex-related, environmental, dietary, and sociocultural factors. Prevalence rates in China range between 0.88 cases/100,000 population in 1986 and 5.2 cases/100,000 population in 2013, with a non-significant upwards trend (p = .08). The increase observed in Japan, where figures ranged between 8.1 and 18.6 cases/100,000 population was highly significant (p < .001). Prevalence rates in countries with predominantly white populations are considerably higher and have increased over time, reaching 115 cases/100,000 population in 2015 (r2 = 0.79, p < .0001). In conclusion, the prevalence of MS in China appears to have risen in recent years, although Asian populations (including Chinese and Japanese populations, among others) appear to present less risk than other populations. Within Asia, geographical latitude appears not to be a determining factor for developing MS.
摘要：
亚洲国家的多发性硬化症（MS）的患病率被认为低于西方国家，亚洲人群的MS风险比白人人群低80%。因此，亚洲国家的发病率和患病率没有很好的定义，它们与邻国的发病率有关联，以及种族，环境,和社会经济因素，不是很了解。我们对来自中国和邻国的流行病学数据进行了全面的文献综述，以研究该疾病的发生频率，专注于患病率，随着时间的推移和性别相关的影响，环境,饮食，和社会文化因素。中国的患病率介于1986年的0.88例/10万人口和2013年的5.2例/10万人口之间，无明显上升趋势（p=.08）。在日本观察到的增长，其中数字范围在8.1和18.6例/100,000人群之间是高度显着（p<.001）。以白种人为主的国家的患病率相当高，而且随着时间的推移有所上升，2015年达到115例/10万人口(r2=0.79，p<0.0001)。总之,近年来，中国的MS患病率似乎有所上升，虽然亚洲人口(包括中国和日本人口，其中)似乎比其他人群风险更低。在亚洲，地理纬度似乎不是发展MS的决定因素。
