Abstract:
Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.
摘要:
最近,生物材料的快速发展引起了人们对骨相关疾病的精确靶向治疗的极大兴趣,包括骨癌,感染,和炎症。实现非侵入性治疗效果,以及改善骨组织再生,对于骨相关疾病治疗的成功至关重要。近年来,研究人员一直致力于开发刺激反应策略来治疗骨相关疾病和实现骨再生。在靶向治疗的各种外界刺激中,近红外(NIR)光由于其高的组织穿透能力而引起了相当大的兴趣,对正常组织的损伤最小,和容易的远程控制属性。本系统综述的主要目的是揭示NIR光辅助光疗在骨相关疾病治疗和骨组织再生中的当前应用。2020年6月1日前完成数据库收集,最终纳入相关研究共81项。我们概述了光热的各种治疗应用,NIR光照射下的光动力和光生物调节效应,用于骨相关疾病治疗和骨再生,根据检索到的文献。此外,总结了NIR光响应给药系统在时空控制治疗中的优势和有希望的应用。这些发现表明,近红外光辅助光疗在骨相关疾病治疗和骨组织再生中起着重要作用。具有进一步的生物医学和临床应用的重要前景。