关键词: CSRP2 Colorectal cancer ERK Hippo PAK
Mesh : Aminoquinolines / pharmacology Animals Biomarkers, Tumor / genetics metabolism Carcinogenesis / drug effects Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects Colon / pathology surgery Colorectal Neoplasms / mortality pathology surgery Crk-Associated Substrate Protein / metabolism Disease Progression Down-Regulation Epithelial-Mesenchymal Transition / drug effects Extracellular Signal-Regulated MAP Kinases / metabolism Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Hippo Signaling Pathway Humans Kaplan-Meier Estimate LIM Domain Proteins / genetics metabolism Male Mice Middle Aged Muscle Proteins / genetics metabolism Neoplasm Invasiveness / pathology Nuclear Proteins / genetics metabolism Phosphorylation Prognosis Protein Serine-Threonine Kinases / metabolism Pyrimidines / pharmacology Rectum / pathology surgery Signal Transduction / drug effects Xenograft Model Antitumor Assays p21-Activated Kinases / metabolism rac1 GTP-Binding Protein / antagonists & inhibitors metabolism
来 源:
DOI:10.7150/thno.45674
PDF(Sci-hub)
PDF(Pubmed)