PDF(Pubmed)
Abstract：
Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the novel coronavirus disease. The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies. The present systematic review was carried out according to the Preferred Reporting Items for Systematic Review (PRISMA) standards. A systematic literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from database inception to June 2020 was performed. We found 28 scientific papers; the total amount of cases is 341. The major histological feature in the lung is diffuse alveolar damage with hyaline membrane formation, alongside microthrombi in small pulmonary vessels. It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed. A uniform COVID-19 post-mortem diagnostic protocol has not yet been developed. In a time in which international collaboration is essential, standardized diagnostic criteria are fundamental requirements.
摘要：
尽管已经发表了许多临床报告，对死于新型冠状病毒病的人的病理性验尸结果知之甚少。迫切需要提供验尸信息，以改善轻度和重度疾病的患者管理，和治疗策略。本系统审查是根据系统审查的首选报告项目（PRISMA）标准进行的。对收集的研究进行了系统的文献检索和批判性审查。PubMed的电子搜索，科学直接Scopus,谷歌学者，并执行了从数据库开始到2020年6月的ExcerptaMedica数据库（EMBASE）。我们发现了28篇科学论文；病例总数为341。肺的主要组织学特征是弥漫性肺泡损伤，伴有透明膜形成，与肺小血管中的微血栓一起。在COVID-19患者中，深静脉血栓形成和肺栓塞的发生率很高，提示内皮受累，但是需要更多的研究。尚未制定统一的COVID-19验尸诊断方案。在国际合作至关重要的时代，标准化诊断标准是基本要求。
