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Abstract：
Postorgasmic illness syndrome (POIS) is a rare syndrome of unknown etiology where patients experience distressing physical and psychological after ejaculatory sequelae.
To better characterize the epidemiology, symptomatology, disease course, and treatment of POIS, with specific interest placed on examining relationships between disease presentation and measures of disease burden.
A 30-item questionnaire was distributed to an online community of patients with POIS from June 2019 to January 2020. We assessed diagnostic criteria and clusters of symptomatology described in prior studies. Outcome measures include self-reported measures of symptom severity, disease burden, and behavioral changes. Statistical correlations were assessed with Pearson\'s chi-squared (χ2) and ordinal regression analyses.
The main outcome measures of this study are self-reported measures of symptom severity, disease burden, and behavioral changes.
The sample consisted of 302 men (mean age: 32.6 ± 11.4 years, mean age of onset: 19.1 ± 7.8 years) with 89% satisfying ≥3 diagnostic criteria. Common symptoms were difficulty concentrating (254, 84%), extreme fatigue (250, 83%), irritability (225, 74%), and muscle weakness (212, 70%). Common symptom clusters were general (219, 72%), muscle (137, 45%), and head (93, 31%). Common behavioral modifications were avoiding masturbation (215, 71%), schedule changes (213, 71%), and abstinence (186, 62%). Head and throat symptom clusters demonstrated worse disease burden outcomes. Professional medical advice was sought by 51% of participants. Attempted treatments included pharmacotherapy, vitamins, supplements, and herbs with variable efficacy.
This study further characterizes POIS, including how patients respond to the condition, how it is treated in the community, and presentations that may be associated with more severe disease.
This is the largest study to date that concerns patients suffering from POIS and includes a diverse, global population. Limitations include that the survey was only administered in English and within 1 online community, that results were self-reported, and that the response rate was low (32%).
Characterizing symptom cluster, but not number of diagnostic criteria, may offer prognostic value, and investigation to elucidate pathophysiology and potential treatments for POIS is necessary. Natale C, Gabrielson A, Tue Nguyen HM, et al. Analysis of the Symptomatology, Disease Course, and Treatment of Postorgasmic Illness Syndrome in a Large Sample. J Sex Med 2020;17:2229-2235.
To better characterize the epidemiology, symptomatology, disease course, and treatment of POIS, with specific interest placed on examining relationships between disease presentation and measures of disease burden.
A 30-item questionnaire was distributed to an online community of patients with POIS from June 2019 to January 2020. We assessed diagnostic criteria and clusters of symptomatology described in prior studies. Outcome measures include self-reported measures of symptom severity, disease burden, and behavioral changes. Statistical correlations were assessed with Pearson\'s chi-squared (χ2) and ordinal regression analyses.
The main outcome measures of this study are self-reported measures of symptom severity, disease burden, and behavioral changes.
The sample consisted of 302 men (mean age: 32.6 ± 11.4 years, mean age of onset: 19.1 ± 7.8 years) with 89% satisfying ≥3 diagnostic criteria. Common symptoms were difficulty concentrating (254, 84%), extreme fatigue (250, 83%), irritability (225, 74%), and muscle weakness (212, 70%). Common symptom clusters were general (219, 72%), muscle (137, 45%), and head (93, 31%). Common behavioral modifications were avoiding masturbation (215, 71%), schedule changes (213, 71%), and abstinence (186, 62%). Head and throat symptom clusters demonstrated worse disease burden outcomes. Professional medical advice was sought by 51% of participants. Attempted treatments included pharmacotherapy, vitamins, supplements, and herbs with variable efficacy.
This study further characterizes POIS, including how patients respond to the condition, how it is treated in the community, and presentations that may be associated with more severe disease.
This is the largest study to date that concerns patients suffering from POIS and includes a diverse, global population. Limitations include that the survey was only administered in English and within 1 online community, that results were self-reported, and that the response rate was low (32%).
Characterizing symptom cluster, but not number of diagnostic criteria, may offer prognostic value, and investigation to elucidate pathophysiology and potential treatments for POIS is necessary. Natale C, Gabrielson A, Tue Nguyen HM, et al. Analysis of the Symptomatology, Disease Course, and Treatment of Postorgasmic Illness Syndrome in a Large Sample. J Sex Med 2020;17:2229-2235.
摘要：
中风后疾病综合征（POIS）是一种病因不明的罕见综合征，患者在射精后遗症后会经历身心困扰。
为了更好地描述流行病学特征，症状学，病程,和POIS的治疗，特别感兴趣的是检查疾病表现和疾病负担测量之间的关系。
从2019年6月至2020年1月，将30项问卷分发给POIS患者的在线社区。我们评估了先前研究中描述的诊断标准和症状分类。结果指标包括症状严重程度的自我报告指标，疾病负担,和行为变化。用Pearson卡方(χ2)和序数回归分析评估统计相关性。
这项研究的主要结果指标是症状严重程度的自我报告指标，疾病负担,和行为变化。
样本包括302名男性（平均年龄：32.6±11.4岁，平均发病年龄：19.1±7.8岁），89%满足≥3诊断标准。常见的症状是注意力不集中（254，84%），极度疲劳（250，83%），烦躁（225，74%），和肌肉无力（212，70%）。常见症状群一般(219，72%)，肌肉（137，45%），头（93，31%）。常见的行为改变是避免手淫（215，71％），进度变更（213，71%），和禁欲（186，62%）。头部和喉咙症状群显示出更差的疾病负担结果。51%的参与者寻求专业医疗建议。尝试的治疗包括药物治疗，维生素,补充剂,和具有可变功效的草药。
这项研究进一步描述了POIS，包括患者对病情的反应，在社区中如何对待它，以及可能与更严重疾病相关的表现。
这是迄今为止最大的研究，涉及患有POIS的患者，全球人口。局限性包括调查仅以英语和1个在线社区进行，结果是自我报告的，反应率很低(32%)。
表征症状簇，但不是诊断标准的数量，可能提供预后价值，和研究以阐明POIS的病理生理学和潜在的治疗方法是必要的。NataleC,加布里埃尔森A,TueNguyenHM,etal.症状学分析，疾病课程，和治疗后疾病综合症的大样本。J性医学2020；17：2229-2235。
为了更好地描述流行病学特征，症状学，病程,和POIS的治疗，特别感兴趣的是检查疾病表现和疾病负担测量之间的关系。
从2019年6月至2020年1月，将30项问卷分发给POIS患者的在线社区。我们评估了先前研究中描述的诊断标准和症状分类。结果指标包括症状严重程度的自我报告指标，疾病负担,和行为变化。用Pearson卡方(χ2)和序数回归分析评估统计相关性。
这项研究的主要结果指标是症状严重程度的自我报告指标，疾病负担,和行为变化。
样本包括302名男性（平均年龄：32.6±11.4岁，平均发病年龄：19.1±7.8岁），89%满足≥3诊断标准。常见的症状是注意力不集中（254，84%），极度疲劳（250，83%），烦躁（225，74%），和肌肉无力（212，70%）。常见症状群一般(219，72%)，肌肉（137，45%），头（93，31%）。常见的行为改变是避免手淫（215，71％），进度变更（213，71%），和禁欲（186，62%）。头部和喉咙症状群显示出更差的疾病负担结果。51%的参与者寻求专业医疗建议。尝试的治疗包括药物治疗，维生素,补充剂,和具有可变功效的草药。
这项研究进一步描述了POIS，包括患者对病情的反应，在社区中如何对待它，以及可能与更严重疾病相关的表现。
这是迄今为止最大的研究，涉及患有POIS的患者，全球人口。局限性包括调查仅以英语和1个在线社区进行，结果是自我报告的，反应率很低(32%)。
表征症状簇，但不是诊断标准的数量，可能提供预后价值，和研究以阐明POIS的病理生理学和潜在的治疗方法是必要的。NataleC,加布里埃尔森A,TueNguyenHM,etal.症状学分析，疾病课程，和治疗后疾病综合症的大样本。J性医学2020；17：2229-2235。
